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Synfacts 2008(4): 0334-0334
DOI: 10.1055/s-2008-1042883
DOI: 10.1055/s-2008-1042883
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of MB06322
Q. Dang, S. R. Kasibhatla, K. R. Reddy, T. Jiang, M. R. Reddy, S. C. Potter, J. M. Fujitaki, P. D. van Poelje, J. Huang, W. N. Lipscomb, M. D. Erion*
Metabasis Therapeutics, La Jolla and Harvard University, Cambridge, USA
Further Information
Publication History
Publication Date:
19 March 2008 (online)
Significance
MB06322 is an orally available phosphonate diamide prodrug to compound D, a potent inhibitor of fructose-1,6-bisphosphatase (FBPase). FBPase is a rate-limiting enzyme in glucose production whose inhibition offers a potential treatment for type 2 diabetes.