Synfacts 2008(4): 0336-0336  
DOI: 10.1055/s-2008-1042887
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cruentaren A

Contributor(s): Philip Kocienski
A. Fürstner*, M. Bindl, L. Jean
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
Further Information

Publication History

Publication Date:
19 March 2008 (online)


Cruentaren A is a metabolite of the myxobacterium Byssovorax cruenta with remarkable cytotoxicity against a panel of human cancer cell lines. Cruentaren A is also a potent inhibitor of F1-ATPase in mammals. A combination of ring-closing alkyne metathesis and Lindlar reduction achieved the efficient synthesis of the Z alkene in the 12-membered lactone ring.