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Synthesis of Cruentaren A
A. Fürstner*, M. Bindl, L. Jean
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
19 March 2008 (online)
Cruentaren A is a metabolite of the myxobacterium Byssovorax cruenta with remarkable cytotoxicity against a panel of human cancer cell lines. Cruentaren A is also a potent inhibitor of F1-ATPase in mammals. A combination of ring-closing alkyne metathesis and Lindlar reduction achieved the efficient synthesis of the Z alkene in the 12-membered lactone ring.