Synfacts 2008(4): 0331-0331  
DOI: 10.1055/s-2008-1042889
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Clusianone

Contributor(s): Philip Kocienski, Stewart Eccles
J. Qi, J. A. Porco, Jr.*
Boston University, USA
Further Information

Publication History

Publication Date:
19 March 2008 (online)


Clusianone is isolated from the floral resin of the Clusia species. It has promising bio­logical activity and the interesting bicyclo[3.3.0] core has made clusianone a popular target. This synthesis utilizes an alkylative dearomatization strategy to construct the bicyclic core.