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Synthesis of (-)-Chaetominine
B. B. Snider*, X. Wu
Brandeis University, Waltham, USA
19 March 2008 (online)
Chaetominine is a modified tripeptide alkaloid isolated from an endophytic fungus known as Chaetomium sp IFBE015 that displays activity against human leukemia K562 and colon cancer SW1116 cell lines. The key step entails a δ-lactamization reaction (E → F) using a catalytic amount of DMAP in refluxing toluene.