Synthesis of Chiral Glutamic Acid By Conjugate Addition

Significance

One of the most efficient preparation methods of glutamic acid derivatives is 1,4-addition of glycine derivatives to α,β-unsaturated esters or amides. The authors report the first dia­stereo- and enantioselective synthesis of 3-substituted glutamic acid derivatives using chiral calcium catalysts. The product could be converted into the free glutamic acid derivatives in good yields.