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Synfacts 2008(5): 0535-0535  
DOI: 10.1055/s-2008-1072682
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York

Biginelli Reaction via Dual Activation

Contributor(s): Benjamin List, Frank Lay
J. Xin, L. Chang, Z. Hou, D. Shang, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publikationsverlauf

Publikationsdatum:
23. April 2008 (online)

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Significance

A new Biginelli reaction catalyzed by a combination of two amine salts gives the corresponding dihydropyrimidinones in moderate to high yields (34-73%) and high to excellent enantio­meric ratios (er = 85:15 up to 99:1).