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Synfacts 2008(9): 0895-0895  
DOI: 10.1055/s-2008-1077986
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Oseltamivir

Contributor(s): Philip Kocienski
B. M. Trost*, T. Zhang
Stanford University, USA
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Publikationsdatum:
22. August 2008 (online)

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Significance

A very concise synthesis of (-)-oseltamivir (tamiflu) features a novel palladium-catalyzed asymmetric allylic alkylation reaction using a phthalimide nucleophile to directly open the racemic lactone A.