PDF herunterladen
Synfacts 2008(9): 0905-0905  
DOI: 10.1055/s-2008-1077991
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Dysibetaine

Contributor(s): Philip Kocienski, Zofia Komsta
J. Isaacson, M. Loo, Y. Kobayashi*
University of California at San Diego, La Jolla, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
22. August 2008 (online)

   Lizenzen und Reprints

Significance

(-)-Dysibetaine was isolated from the marine sponge Dysidea herbacea. The compound potentially interacts with the glutamate receptors in the central nervous system. The key step of the synthesis is the four-center-three-component Ugi reaction (D → F).