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Synfacts 2008(8): 0782-0782  
DOI: 10.1055/s-2008-1078529
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Pinnatoxin A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
C. E. Stivala, A. Zakarian*
Florida State University, Tallahassee, USA
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

(+)-Pinnatoxin A is a neurotoxin found in the Pinna shellfish species, presumably acting as a calcium-channel activator. The present study concentrates on a new approach towards ring G using an Ireland-Claisen rearrangement to establish the C5 and C31 stereogenic centers.