Synthesis of (-)-Ulapualide A

G. Pattenden; N. J. Ashweek; C. A. G. Baker-Glenn; J. Kempson; G. M. Walker; J. G. K. Yee

doi:10.1055/s-2008-1078536

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Synfacts 2008(8): 0784-0784
DOI: 10.1055/s-2008-1078536

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Ulapualide A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
G. Pattenden*, N. J. Ashweek, C. A. G. Baker-Glenn, J. Kempson, G. M. Walker, J. G. K. Yee
University of Nottingham, UK

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Publication History

Publication Date:
23 July 2008 (online)

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Significance

The ulapualides are macrolides isolated from sea slugs. They feature three continuously linked oxazoles as well as an N-formyl enamine-terminated polyol side chain. Antifungal and ichthyotoxic properties have been reported.