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Synfacts 2008(8): 0876-0876
DOI: 10.1055/s-2008-1078538
DOI: 10.1055/s-2008-1078538
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Thiourea/DMAP-Catalyzed Cascade Reaction
L.-Q. Lu, Y.-J. Cao, X.-P. Liu, J. An, C.-J. Yao, Z.-H. Ming, W.-J. Xiao*
Central China Normal University, Wuhan, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Juli 2008 (online)
Significance
A new organocatalytic cascade reaction of stable sulfur ylides and nitroolefins catalyzed by thiourea 1 and DMAP to afford diverse oxazolidin-2-ones with high diastereoselectivities is reported. The scope of the nitroolefins and the sulfur ylides has been studied. Too stable or too sterically hindered ylides cannot be employed by this protocol. Furthermore a catalytic cycle is proposed that involves intermediates A and B, which is supported by D- and ¹³C-labeling experiments.