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J Pediatr Intensive Care 2014; 03(03): 147-157
DOI: 10.3233/PIC-14098
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Idiopathic pneumonia syndrome following hematopoietic stem cell transplantation

Orly R. Klein
a   Department of Oncology, Division of Pediatric Hematology/Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
,
Kenneth R. Cooke
a   Department of Oncology, Division of Pediatric Hematology/Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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Further Information

Publication History

12 August 2014

19 September 2014

Publication Date:
28 July 2015 (online)

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Abstract

Non-infectious lung injury following hematopoietic stem cell transplant may be driven by either immune or non-immune pathways of inflammation. Common alloimmune lung complications include idiopathic pneumonia syndrome (IPS), transfusion related lung injury, diffuse alveolar hemorrhage, and peri-engraftment respiratory distress syndrome, with both diffuse alveolar hemorrhage and peri-engraftment respiratory distress syndrome existing as subsets of IPS when infection is absent. This review will discuss the definitions, risk factors, and pathogeneses of IPS and highlight the diagnostic work-up and novel approaches to treatment.

Keywords

Hematopoietic stem cell - idiopathic pneumonia syndrome - diffuse alveolar hemorrhage - respiratory distress syndrome