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Acute central nervous system complications in pediatric hematopoietic stem cell patients
02 August 2014
02 November 2014
28 July 2015 (online)
Acute neurologic complications in pediatric hematopoietic stem cell transplant (HSCT) patients cause significant morbidity and mortality. To conduct a comprehensive review of the existing literature reporting acute neurologic complications of the central nervous system among children undergoing HSCT. Comprehensive literature review from 2000 to 2014 using Medline. A total of 566 pediatric articles were reviewed and data from 66 studies selected. A brief overview of morbidity and mortality in pediatric HSCT patients is provided followed by a summary of findings related to acute neurologic complications. Acute central nervous system complications in pediatric HSCT patients are varied and are the result of multiple causes including infection, drug-related toxicity, immune suppression, vascular injury and neoplasms.