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Klin Monbl Augenheilkd 2019; 236(11): 1283-1291
DOI: 10.1055/a-0972-1625
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Pathogenese und Therapie der nicht arteriitischen anterioren ischämischen Optikusneuropathie

Non-arteritic Anterior Ischaemic Optic Neuropathy: Pathogenesis and Therapeutic Approaches
Christian van Oterendorp
1   Klinik für Augenheilkunde, Universitätsmedizin Göttingen
,
Wolf A. Lagrèze
2   Klinik für Augenheilkunde, Universitätsklinikum und Medizinische Fakultät Freiburg
,
Nicolas Feltgen
1   Klinik für Augenheilkunde, Universitätsmedizin Göttingen
› Author Affiliations
Further Information

Publication History

eingereicht 13 May 2019

akzeptiert 04 July 2019

Publication Date:
11 November 2019 (online)

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Zusammenfassung

Die nicht arteriitische anteriore ischämische Optikusneuropathie (NAION) ist eine akute Sehnervendegeneration, deren Pathogenese in großen Teilen unerforscht ist. Für sie existiert derzeit keine allgemein akzeptierte Behandlungsmöglichkeit. Die Etablierung von AION-Tiermodellen sowie die Ergebnisse größerer epidemiologischer Studien ermöglichten es in den vergangenen Jahren, ein besseres Verständnis der Pathophysiologie und möglicher Einflussfaktoren zu gewinnen. Basierend auf diesen Erkenntnissen testeten und testen klinische und tierexperimentelle Studien eine große Bandbreite möglicher Behandlungsansätze. Unabhängig von ihrem jeweiligen Ergebnis können diese Untersuchungen unser Verständnis der NAION erheblich erweitern und auch für andere Sehnervendegenerationen von großer Bedeutung sein.

Abstract

Non-arteritic anterior ischemic optic neuropathy (NAION) is an acute neurodegenerative disease with a largely elusive early pathogenesis and no specific therapy. Recent data from animal models of the disease as well as from epidemiological studies have provided new insights into the disease mechanism of NAION. On the basis of this new knowledge, a broad variety of therapeutic approaches is currently being evaluated in animal and clinical studies. This review aims to provide an overview of the pathogenesis as well as neuroprotective therapeutic concepts of recent and currently running studies.

Schlüsselwörter

nicht arteriitische anteriore ischämische Optikusneuropathie - Steroide - Caspase-Inhibition

Key words

non-arteritic anterior ischemic optic neuropathy - steroids - caspase-inhibition
 

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