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Klin Monbl Augenheilkd 2020; 237(09): 1087-1092
DOI: 10.1055/a-1142-6442
Experimentelle Studie

Tiefenwirkung von kaltem Atmosphärendruckplasma in der Keratitistherapie: ein Hornhautstromagewebemodell

Depth Effect of Cold Atmospheric Pressure Plasma in Keratitis Therapy: A Corneal Stroma Tissue Model
Christian Lingenfelder‡
1   Business Development, PHARMPUR GmbH, Königsbrunn
,
Jürgen Kampmeier‡
2   Augenklinik, Universitätsklinikum Ulm
,
Detlef Russ
3   Institut für Lasertechnologien in der Medizin und Messtechnik an der Universität Ulm
,
Rainer Wittig
3   Institut für Lasertechnologien in der Medizin und Messtechnik an der Universität Ulm
,
Christof Diener
4   Diener electronic GmbH + Co. KG, Ebhausen
,
Jens Ulrich Werner
2   Augenklinik, Universitätsklinikum Ulm
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Zusammenfassung

Die Inzidenz der mikrobiellen Keratitis steigt an und liegt bei 28 Fällen/100 000 Einwohner. Dies könnte auf das häufigere Tragen von Kontaktlinsen zurückzuführen sein. Die Keratitis kann zu Sehbehinderungen und in schweren Fällen mit Endophthalmitis zur Enukleation des betroffenen Auges führen. Zunehmende Resistenzen von Mikroorganismen gegen die Antibiotikatherapie zeigen den Bedarf an neuen therapeutischen Strategien auf. Kaltes Atmosphärendruckplasma wurde bereits erfolgreich zur Desinfektion von Oberflächen eingesetzt. Diese Studie untersucht in einem Hornhautstromagewebemodell tiefenaufgelöst die Wirksamkeit von kaltem Atmosphärendruckplasma gegen Escherichia coli.

Abstract

The incidence of microbial keratitis has been increasing and is now 28 cases/100,000 inhabitants; this may be due to the more frequent use of contact lenses. Keratitis can lead to visual impairment and in severe cases with endophthalmitis to enucleation of the affected eye. As microorganisms are becoming more resistant to antibiotic therapy, there is a need for new therapeutic strategies. Cold atmospheric pressure plasma has already been successfully used to disinfect surfaces. This study investigates the efficacy of cold atmospheric pressure plasma against Escherichia coli in a depth-resolved corneal stroma tissue model.

Schlüsselwörter

Keratitis - Ulkus - Plasma

Key words

keratitis - ulcer - plasma


Publication History

Received: 05 December 2019

Accepted: 12 March 2020

Article published online:
20 May 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 

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