Epigenetische Mechanismen bei Adipositas: Finetuning der Genaktivität durch DNA-Methylierung – Bertram-Preis 2020 – eine Kurzübersicht der Preisträgerin Yvonne Böttcher

Adipositas und ihre metabolischen Begleiterkrankungen wie Typ-2-Diabetes (T2 D), Bluthochdruck und Dyslipidämie zählen zu den häufigsten Volkskrankheiten weltweit [1], und ihre Therapie belastet die nationalen Gesundheitssysteme enorm. Die Häufigkeit von Adipositas hat sich in den letzten Jahrzehnten dramatisch erhöht [2] und ist Folge eines Zusammenspiels zwischen genetischer Veranlagung und ungünstigen Umwelteinflüssen (z. B. energiedichte Ernährung, mangelnde Bewegung; [Abb. 1]). Neben dem Body-Mass-Index (BMI) ist die Körperfettverteilung ein wichtiger Prädiktor für das Risiko, an metabolischen Komorbiditäten zu erkranken. So ist insbesondere die viszeral betonte Adipositas häufiger mit Sekundärerkrankungen verbunden [3] [4].

Publication History

Article published online:
08 December 2020

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