The complex advanced endoscopic approach in the treatment of choledocholitiasis and empyema of gallbladder

Advanced endoscopic procedures using a cholangioscope and performed under the endoscopic ultrasound (EUS) guidance for minimally invasive therapy of complex biliary diseases has become a promising treatment modality in selected cases [1] [2] [3].

An 88-year-old man was admitted to the surgical department with clinical signs of cholangitis. Imaging revealed a gallbladder empyema with dilation of the common bile duct (CBD) up to 25 mm.

During endoscopic retrograde cholangiopancreatography (ERCP), biliary stones in the CBD up to 20 × 30 mm were seen. Sphincterotomy allowed drainage of purulent bile and sludge and was followed by mechanical lithotripsy, without success. Lastly, a biliary stent was implanted in the CBD.

Owing to the gallbladderʼs empyema and severe comorbidities that dramatically increased operative risk, the patient qualified for gallbladder decompression through a cholecystogastrostomy under EUS guidance using a Hot Axios stent (10 × 10 mm) (Boston Scientific, Marlborough, Massachusetts, USA) ([Fig. 1]). No intra- or postprocedural complications were observed, allowing safe discharge home 3 days later.

Fig. 1 Cholecystogastrostomy under endoscopic ultrasound guidance using a Hot Axios stent (10 × 10 mm).

A second ERCP for common bile duct stone clearance with a successful cholangioscopy (SpyGlass, SpyScope, Boston Scientific) and electrohydraulic lithotripsy (EHL) (Autolith Touch Biliary EHL System, Boston Scientific) of the largest CBD stone was performed.

The patientʼs general state of health disqualified him from surgery. Thus, a cholecystoscopy through the lumen of the previously implanted lumen-apposing metal stent (LAMS) using the SpyScope cholangioscope was done (via the working channel of the colonoscope) ([Fig. 2]). Numerous gallstones were found, some of them larger than the LAMS lumen. Therefore, EHL of stones was performed, enabling the removal of smaller fragments from the gallbladder into the stomach using a mesh. Cholecystoscopy after stone removal showed a healthy gallbladder wall and no obstruction at the cystic duct ([Fig. 3], [Fig. 4)]. The patient was discharged home on the first day after the procedure. Presently the patient remains in good health with no symptoms.

Fig. 2 Cholecystoscopy through the lumen of the lumen-apposing metal stent.

Fig. 3 Revision of the gallbladder with SpyScope after electrohydraulic lithotripsy.

Fig. 4 Gallbladder after removal of stones confirmed on fluoroscopy.

This case is interesting for three main reasons. First, we demonstrate that the emphysematous gallbladderʼs endoscopic drainage is safe in a high-risk surgical candidate. Second, we show that intra-gallbladder EHL is feasible entering through the previous LAMS. Third, we used the Spyglass system through the colonoscope, which allows for a forward view, in contrast to using it through a duodenoscope. In sum, EUS-guided cholecytogastrostomy followed by Spyglass cholecystoscopy and lithotripsy allows radical treatment of gallbladder empyema and cholelithiasis simultaneously with ERCP treatment of choledocholithiasis ([Video 1]).

Video 1 Endoscopic ultrasound-guided cholecystogastrostomy followed by cholangioscopy with Spyglass through the lumen of the lumen-apposing metal stent and lithotripsy of gallbladder stones.

Endoscopy_UCTN_Code_TTT_1AR_2AH

 

MissingLinkText

Competing interests

The authors declare that they have no conflict of interest.

• References

• 1 Oh D, Song TJ, Cho DH. et al. EUS-guided cholecystostomy versus endoscopic transpapillary cholecystostomy for acute cholecystitis in high-risk surgical patients. Gastrointest Endosc 2019; 89: 289-298
• 2 James TW, Baron TH. EUS-guided gallbladder drainage: a review of current practices and procedures. Endosc Ultrasound 2019; 8: S28-S34
• 3 Chaudhary S, Sun S. Endoscopic ultrasound-guided gallbladder drainage: redefines the boundaries. Endosc Ultrasound 2016; 5: 281-283

Publication History

Article published online:
05 March 2021