Corneal Parameters in Patients with Multiple Sclerosis: A Pilot Study

Abstract

Objective To evaluate the corneal topographic parameter values measured with the Pentacam Scheimpflug system in patients with multiple sclerosis (MS).

Methods A total of 108 eyes of 62 MS patients were studied. In addition to a complete examination of anterior and posterior segments, all patients were scanned using the Pentacam Scheimpflug camera. The diagnosis of MS was made according to the McDonald criteria. All MS patients were clinically assessed using the Multiple Sclerosis Severity Score (MSSS).

Results The mean age was 38.89 ± 10.18 years (36.16 – 41.30) for MS patients and 40.94 ± 9.44 years (38.49 – 43.11) for the controls (p = 0.26). Only central corneal thickness (CCT) and corneal volume (CV) values were significantly lower in MS patients (p < 0.001). The other corneal parameters were not significantly different between the study eyes and control eyes (p > 0.05 for all). Pachymetric measurements at the corneal apex were 525.69 ± 29.35 (518.29 – 533.67) µm for the study eyes versus 563.13 ± 23.70 (562.13 – 576.36) µm for the control eyes. CV were 59.22 ± 4.11(58.18 – 60.20) mm³ for the study eyes versus 62.78 ± 3.09 (62.38 – 64.00) mm³ for the control eyes.

Conclusion This is the first study that has reported lower CCT and CV measurements in MS patients than healthy subjects of a similar age. These results should be supported by further studies.

Zusammenfassung

Ziel Auswertung der mit dem Pentacam-Scheimpflug-System gemessenen topografischen Parameterwerte der Hornhaut bei Patienten mit multipler Sklerose (MS).

Methoden Insgesamt wurden 108 Augen von 62 MS-Patienten untersucht. Zusätzlich zu einer vollständigen Untersuchung des vorderen und hinteren Segments wurden alle Patienten mit der Pentacam-Scheimpflug-Kamera gescannt. Die Diagnose von MS wurde nach den McDonald-Kriterien gestellt. Alle MS-Patienten wurden klinisch unter Verwendung des Multiple Sclerosis Severity Score (MSSS) bewertet.

Ergebnisse Das Durchschnittsalter betrug 38,89 ± 10,18 Jahre (36,16 – 41,30) für MS-Patienten und 40,94 ± 9,44 Jahre (38,49 – 43,11) für die Kontrollen (p = 0,26). Nur die Werte für die zentrale Hornhautdicke (CCT) und das Hornhautvolumen (CV) waren bei MS-Patienten signifikant niedriger (p < 0,001). Die anderen Hornhautparameter unterschieden sich nicht signifikant zwischen den Studienaugen und den Kontrollaugen (p > 0,05 für alle). Pachymetrische Messungen an der Hornhautspitze betrugen 525,69 ± 29,35 (518,29 – 533,67) µm bei den Studienaugen gegenüber 563,13 ± 23,70 (562,13 – 576,36) µm bei den Kontrollaugen. Das CV betrug 59,22 ± 4,11 (58,18 – 60,20) mm³ bei den Studienaugen gegenüber 62,78 ± 3,09 (62,38 – 64,00) mm³ bei den Kontrollaugen.

Schlussfolgerung Dies ist die erste Studie, die über niedrigere CCT- und CV-Messungen bei MS-Patienten als bei gesunden Probanden ähnlichen Alters berichtet. Diese Ergebnisse sollten durch weitere Studien gestützt werden.

Key words

multiple sclerosis - corneal thickness - corneal volume - Pentacam

Schlüsselwörter

multiple Sklerose - Hornhautdicke - Hornhautvolumen - Pentacam

Publication History

Received: 16 March 2021

Accepted: 28 April 2021

Article published online:
09 July 2021

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