Transition-Metal-Catalyzed Hydroxylation Reaction of Aryl Halide for the Synthesis of Phenols

Abstract

Phenols are important components of pharmaceuticals, biologically active natural products, and materials. Here, we briefly discuss recent advances in catalytic hydroxylation reactions for the synthesis of phenols, with particular attention to our recent work. H₂O is proved to be an efficient hydroxide reagent in converting (hetero)aryl halides into the corresponding phenols under synergistic organophotoredox and nickel catalysis. Aryl bromides as well as less reactive aryl chlorides show high reactivity in this catalytic system. This methodology can be applied to the efficient synthesis of diverse phenols and allows the hydroxylation of multifunctional pharmaceutically relevant aryl halides.

1 Introduction

2 Representative Methods for Transition-Metal-Catalyzed Hydroxylation of (Hetero)Aryl Halides

3 Organophotoredox/Ni Dual Catalytic Hydroxylation of Aryl Halides with Water

4 Summary and Outlook

Key words

hydroxylation - aryl halides - photoredox catalysis - nickel catalysis - BODIPY

Publication History

Received: 02 August 2021

Accepted after revision: 24 August 2021

Accepted Manuscript online:
24 August 2021

Article published online:
01 October 2021

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