Download PDF
Ernährung & Medizin 2022; 37(02): 72-76
DOI: 10.1055/a-1743-8089
Wissen

In memoriam Lester Packer: Die 4 Meilensteine der Vitamin-E-Forschung

Ute Obermüller-Jević
,
Karlheinz Schmidt
› Further Information
    Permissions and Reprints

Lester Packer (1929–2018) war ein Pionier der Vitamin-E-Forschung. Er hat als Erster erkannt, dass bei der Redox-Regulation von Zellen und Geweben und insbesondere deren Anpassung an oxidativen Stress ein ganzes System von Komponenten zusammenwirken muss, und dass Vitamin E dabei eine zentrale Rolle einnimmt. Einer der Meilensteine in der Vitamin-E-Forschung!



Publication History

Article published online:
07 June 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Evans HM, Bishop KS. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 1922; 56: 650
    CrossrefPubMedGoogle Scholar
  • 2 Evans HM, Burr GO. The anti-sterility vitamin fat soluble E. Proc Natl Acad Sci USA 1925; 11: 334-342
    CrossrefPubMedGoogle Scholar
  • 3 Evans HM. Invariable occurrence of male sterility with dietaries lacking fat soluble vitamine E. Proc Natl Acad Sci USA 1925; 11: 373-377
    CrossrefPubMedGoogle Scholar
  • 4 Evans H, Emerson OH, Emerson G. The isolation from wheat germ oil of an alcohol, alpha-tocopherol, having the properties of vitamin E. J Biol Chem 1936; 113: 319-332
    CrossrefPubMedGoogle Scholar
  • 5 Leth T, Sondergaard H. Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds. J Nutr 1977; 107: 2236-2243
    CrossrefPubMedGoogle Scholar
  • 6 Tappel AL. Vitamin E as the biological lipid antioxidant. Vitam Horm 1962; 20: 493-510
    CrossrefPubMedGoogle Scholar
  • 7 Tappel AL. Free-radical lipid peroxidation damage and its inhibition by vitamin E and selenium. Fed Proc 1965; 24: 73
    PubMedGoogle Scholar
  • 8 Kamal-Eldin A, Appelqvist L. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996; 31: 671-701
    CrossrefPubMedGoogle Scholar
  • 9 Schauenstein E, Esterbauer H, Jang G, Taufer M. Über die Wirkung von Aldehyden auf gesunde und maligne Zellen, 1. Mitt.: Hydroxyoctenal, ein neuer Fettaldehyd. Monatsh Chem 1964; 95: 180-183
    CrossrefPubMedGoogle Scholar
  • 10 Packer L, Smith JR. Extension of the lifespan of cultured normal human diploid cells by vitamin E: a reevaluation. Proc Natl Acad Sci USA 1977; 74: 1640-1641
    CrossrefPubMedGoogle Scholar
  • 11 Packer L, Landvik S. Vitamin E: introduction to biochemistry and health benefits. Ann NY Acad Sci 1989; 570: 1-6
    CrossrefPubMedGoogle Scholar
  • 12 Packer L, Obermüller-Jević UC. Vitamin E in disease prevention and therapy: Future perspectives. In: Packer L, Traber MG, Kraemer K, Frei B, eds. The Antioxidant Vitamins C and E. Champaign IL: AOCS; 2002: 255-288
    Google Scholar
  • 13 Maguire JJ, Wilson DS, Packer L. Mitochondrial electron transport linked tocopheroxyl radical reduction. J Biol Chem 1989; 264: 21462-21465
    CrossrefPubMedGoogle Scholar
  • 14 Halliwell B. Free radical reactions in human disease. In: Fuchs I, Packer L, eds. Environmental Stressors in Health and Disease. New York: Marcel Dekker; 2001: 1-16
    Google Scholar
  • 15 Kagan VE, Packer L. Light-induced generation of vitamin E radicals: assessing vitamin E regeneration. Methods Enzymol 1994; 234: 316-320
    CrossrefPubMedGoogle Scholar
  • 16 Shindo Y, Witt E, Han D, Packer L. Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis. J Invest Dermatol 1994; 102: 470-475
    CrossrefPubMedGoogle Scholar
  • 17 Kitazawa M, Podda M, Thiele J. et al. Interactions between vitamin E homologues and ascorbate free radicals in murine skin homogenates irradiated with ultraviolet light. Photochem Photobiol 1997; 65: 355-365
    CrossrefPubMedGoogle Scholar
  • 18 Thiele JJ, Traber MG, Polefka TG. et al. Ozone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum. J Invest Dermatol 1997; 108: 753-757
    CrossrefPubMedGoogle Scholar
  • 19 Thiele JJ, Traber MG, Tsang K. et al. In vivo exposure to ozone depletes vitamins C and E and induces lipid peroxidation in epidermal layers of murine skin. Free Radic Biol Med 1997; 23: 385-391
    CrossrefPubMedGoogle Scholar
  • 20 Thiele JJ, Traber MG, Packer L. Depletion of human Stratum corneum vitamin E: an early and sensitive in vivo marker of UV induced photo-oxidation. J Invest Dermatol 1998; 110: 756-756
    CrossrefPubMedGoogle Scholar
  • 21 Thiele JJ, Schroeter C, Hsieh SN. et al. The antioxidant network of the Stratum corneum. Curr Probl Dermatol 2001; 29: 26-42
    CrossrefPubMedGoogle Scholar
  • 22 Valacchi G, Pagnin E, Corbacho AM. et al. In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin. Free Radic Biol Med 2004; 36: 673-681
    CrossrefPubMedGoogle Scholar
  • 23 Hiramatsu M, Velasco RD, Wilson DS, Packer L. Ubiquinone protects against loss of tocopherol in rat liver microsomes and mitochondrial membranes. Res Commun Chem Pathol Pharmacol 1991; 72: 231-241
    PubMedGoogle Scholar
  • 24 Reznick AZ, Witt E, Matsumoto M, Packer L. Vitamin E inhibits protein oxidation in skeletal muscle of resting and exercised rats. Biochem Biophys Res Commun 1992; 189: 801-806
    CrossrefPubMedGoogle Scholar
  • 25 Witt EH, Reznick AZ, Viguie CA. et al. Exercise, oxidative damage and effects of antioxidant manipulation. J Nutr 1992; 122: 766-773
    CrossrefPubMedGoogle Scholar
  • 26 Blaner WS, Shmarakov IO, Traber MG. Vitamin A and vitamin E: Will the real antioxidant please stand up?. Annu Rev Nutr 2021; 41: 105-131
    CrossrefPubMedGoogle Scholar
  • 27 Mahoney CW, Azzi A. Vitamin E inhibits protein kinase C activity. Biochem Biophys Res Commun 1988; 154: 694-697
    CrossrefPubMedGoogle Scholar
  • 28 Nishizuka Y. The protein kinase C family and lipid mediators for transmembrane signaling and cell regulation. Alcohol Clin Exp Res 2001; 25: 3s-7s
    CrossrefPubMedGoogle Scholar
  • 29 Tasinato A, Boscoboinik D, Bartoli GM. et al. d-α-Tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci USA 1995; 92: 12190-12194
    CrossrefPubMedGoogle Scholar
  • 30 Khadangi F, Azzi A. Vitamin E – the next 100 years. IUBMB Life 2019; 71: 411-415
    CrossrefPubMedGoogle Scholar
  • 31 Ouahchi K, Arita M, Kayden H. et al. Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet 1995; 9: 141-145
    CrossrefPubMedGoogle Scholar
  • 32 Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr 2007; 27: 347-362
    CrossrefPubMedGoogle Scholar