The Conceptual Development of a Conjunctive Olefination

Dario Filippini; Mattia Silvi

doi:10.1055/a-1787-1159

Synlett, Table of Contents

Synlett 2022; 33(11): 1011-1016
DOI: 10.1055/a-1787-1159

synpacts

The Conceptual Development of a Conjunctive Olefination

Dario Filippini

^aGSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Jubilee Campus, 6 Triumph Rd, Nottingham NG7 2GA, UK

^bSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK

,

Mattia Silvi ∗

^aGSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Jubilee Campus, 6 Triumph Rd, Nottingham NG7 2GA, UK

^bSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK

› Author Affiliations

Abstract

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Abstract

We recently discovered a functional group tolerant and transition-metal-free conjunctive olefination reaction with applications in late-stage functionalization chemistry. In this Synpacts contribution, we analyze the conceptual background that has stimulated the discovery of this reactivity and reflect on the key aspects of its development.

1 Introduction

2 Conceptual Background

2.1 Photoredox-Mediated Giese Reaction

2.2 Photoredox Radical-Polar Reactivity

3 The Development of the Process

4 Conclusion

Key words

photoredox catalysis - Wittig reaction - radical-polar crossover - conjunctive olefination - radical chemistry

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References

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