Download PDF
Erfahrungsheilkunde 2023; 72(06): 366-375
DOI: 10.1055/a-2188-5046
Praxis

Regulationsstörung beim Säugling – aktuelle Ergebnisse einer Behandlungsoption mit einem anthroposophischen Komplexarzneimittel

Kim Gruber‡
,
Ilona Zilkowski
,
Nora Mörbt
,
Peter Vögele
,
Florian C. Stintzing‡
,
Claudia Turek‡
› Further Information
    Permissions and Reprints

Zusammenfassung

In einer multizentrischen prospektiven nicht interventionellen Studie haben wir die Anwendung eines Komplexarzneimittels mit Extrakten aus Kümmel, Kamille, Tollkirsche und Tabak bei Säuglingen mit Bauchbeschwerden, Unruhezuständen sowie Schlafstörungen untersucht. Ziel war es, Daten zur Anwendung, Sicherheit, Verträglichkeit, zum Therapieverlauf und zur Akzeptanz der Behandlung zu erfassen. Hebammen, Kinderärzt*innen und Eltern dokumentierten die Behandlung von Säuglingen unter einem Jahr, die aufgrund der oben genannten Symptome das Arzneimittel Carum carvi comp. Säuglingszäpfchen (WALA Heilmittel GmbH, Bad Boll, Deutschland) erhielten. Vom ersten bis zum letzten Beobachtungstag gab es eine signifikante Reduktion der Beschwerden und der Schreidauer, während sich die Schlafdauer signifikant erhöhte. Therapieverlauf und Verträglichkeit wurden als „gut“ oder „sehr gut“ bewertet. Die Anwendung war sicher, führte zu einer Verringerung der Beschwerden und wurde mehrheitlich positiv bewertet.

Abstract

We conducted a multicenter prospective noninterventional study to evaluate the use of a complex drug containing extracts from caraway, chamomile, deadly nightshade, and tobacco in infants with abdominal complaints as well as associated states of restlessness and sleep disorders. We aimed to examine the modalities of application, safety, tolerability, the course of therapy and the acceptance of the treatment. Midwives, pediatricians, and parents documented the treatment of infants under one year of age who received the drug Carum carvi comp. Säuglingszäpfchen (WALA Heilmittel GmbH, Bad Boll, Germany) because of the symptoms named above. Individual complaints and crying time were reduced significantly from the first to the last observation day while sleep duration increased significantly. The course of therapy and the tolerability were rated as “good” or “very good”. The application was safe, reduced complaints and was positively assessed by the majority.

Schlüsselwörter

Säuglinge - Bauchbeschwerden - Unruhezustände - Schlafstörungen - exzessives Schreien

Keywords

infants - abdominal complaints - state of restlessness - sleep disorders - excessive crying


Publication History

Article published online:
29 November 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Soltis J. The signal functions of early infant crying. Behav Brain Sci 2004; 27 (4) 443-458 discussion 459–490
    CrossrefPubMedGoogle Scholar
  • 2 Vagedes J, Soldner G. Das Kinder Gesundheitsbuch: Kinderkrankheiten ganzheitlich vorbeugen und heilen. München: Gräfe und Unzer; 2008
    Google Scholar
  • 3 Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie und Psychotherapie. Leitlinien zu Diagnostik und Therapie von psychischen Störungen im Säuglings-, Kindes- und Jugendalter: Mit 9 Tabellen. 3. Köln: Deutscher Ärzte-Verlag; 2007
    Google Scholar
  • 4 ZERO TO THREE. DC:0–5TM . Diagnostic classification of mental health and developmental disorders of infancy and early childhood. Washington, DC: Author; 2016
    Google Scholar
  • 5 Lucassen PL, Assendelft WJ, van Eijk JT. et al. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child 2001; 84 (5) 398-403
    CrossrefPubMedGoogle Scholar
  • 6 Vandenplas Y, Abkari A, Bellaiche M. et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015; 61 (5) 531-537
    CrossrefPubMedGoogle Scholar
  • 7 Wessel MA, Cobb JC, Jackson EB. et al. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics 1954; 14 (5) 421-435
    CrossrefPubMedGoogle Scholar
  • 8 Benninga MA, Faure C, Hyman PE. et al. Childhood functional gastrointestinal disorders: Neonate/toddler. Gastroenterology 2016; 150: 1443-1455
    CrossrefPubMedGoogle Scholar
  • 9 Mai T, Fatheree NY, Gleason W. et al. Infantile colic: New insights into an old problem. Gastroenterol Clin North Am 2018; 47 (4) 829-844
    CrossrefPubMedGoogle Scholar
  • 10 James-Roberts IS, Bargn JG, Peter B. et al. Individual differences in responsivity to a neurobehavioural examination predict crying patterns of 1-week-old infants at home. Dev Med Child Neurol 2003; 45 (6) 400-407
    CrossrefPubMedGoogle Scholar
  • 11 Leuchter RH-V, Darque A, Hüppi PS. Brain maturation, early sensory processing, and infant colic. J Pediatr Gastroenterol Nutr 2013; 57 (1) 18-25
    CrossrefPubMedGoogle Scholar
  • 12 Barr RG. Changing our understanding of infant colic. Arch Pediatr Adolesc Med 2002; 156 (12) 1172-1174
    CrossrefPubMedGoogle Scholar
  • 13 Dubois NE, Gregory KE. Characterizing the intestinal microbiome in infantile colic: Findings based on an integrative review of the literature. Biol Res Nurs 2016; 18 (3) 307-315
    CrossrefPubMedGoogle Scholar
  • 14 Pärtty A, Kalliomäki M, Salminen S. et al. Infantile colic is associated with low-grade systemic inflammation. J Pediatr Gastroenterol Nutr 2017; 64 (5) 691-695
    CrossrefPubMedGoogle Scholar
  • 15 Nation ML, Dunne EM, Joseph SJ. et al. Impact of Lactobacillus reuteri colonization on gut microbiota, inflammation, and crying time in infant colic. Sci Rep 2017; 7 (1) 15047
    CrossrefPubMedGoogle Scholar
  • 16 Weerth C de, Fuentes S, Vos WM de. Crying in infants: On the possible role of intestinal microbiota in the development of colic. Gut Microbes 2013; 4 (5) 416-421
    CrossrefPubMedGoogle Scholar
  • 17 Savino F, Quartieri A, Marco A de. et al. Comparison of formula-fed infants with and without colic revealed significant differences in total bacteria, Enterobacteriaceae and faecal ammonia. Acta Paediatr 2017; 106 (4) 573-578
    CrossrefPubMedGoogle Scholar
  • 18 Eutamène H, Garcia-Rodenas CL, Yvon S. et al. Luminal contents from the gut of colicky infants induce visceral hypersensitivity in mice. Neurogastroenterol Motil 2017; 29 (4) e12994
    CrossrefPubMedGoogle Scholar
  • 19 Mayer EA, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest 2015; 125 (3) 926-938
    CrossrefPubMedGoogle Scholar
  • 20 Camilleri M, Park S-Y, Scarpato E. et al. Exploring hypotheses and rationale for causes of infantile colic. Neurogastroenterol Motil 2017; 29 (2) e12943
    CrossrefPubMedGoogle Scholar
  • 21 Talvik I, Alexander RC, Talvik T. Shaken baby syndrome and a baby’s cry. Acta Paediatr 2008; 97 (6) 782-785
    CrossrefPubMedGoogle Scholar
  • 22 Barr RG, Trent RB, Cross J. Age-related incidence curve of hospitalized Shaken Baby Syndrome cases: Convergent evidence for crying as a trigger to shaking. Child Abuse Negl 2006; 30 (1) 7-16
    CrossrefPubMedGoogle Scholar
  • 23 Howard CR, Lanphear N, Lanphear BP. et al. Parental responses to infant crying and colic: The effect on breastfeeding duration. Breastfeed Med 2006; 1 (3) 146-155
    CrossrefPubMedGoogle Scholar
  • 24 Indrio F, Dargenio VN, Francavilla R. et al. Infantile colic and long-term outcomes in childhood: A narrative synthesis of the evidence. Nutrients 2023; 15 (3) 615
    CrossrefPubMedGoogle Scholar
  • 25 Zeevenhooven J, Bruin FE de, Schappin R. et al. Follow-up of infants with colic into childhood: Do they develop behavioural problems?. J Paediatr Child Health 2022; 58 (11) 2076-2083
    CrossrefPubMedGoogle Scholar
  • 26 Hemmi MH, Wolke D, Schneider S. Associations between problems with crying, sleeping and/or feeding in infancy and long-term behavioural outcomes in childhood: A meta-analysis. Arch Dis Child 2011; 96 (7) 622-629
    CrossrefPubMedGoogle Scholar
  • 27 Ellwood J, Draper-Rodi J, Carnes D. Comparison of common interventions for the treatment of infantile colic: A systematic review of reviews and guidelines. BMJ Open 2020; 10 (2) e035405
    CrossrefPubMedGoogle Scholar
  • 28 Biagioli E, Tarasco V, Lingua C. et al. Pain-relieving agents for infantile colic. Coch Libr 2016; 9 (9) CD009999
    PubMedGoogle Scholar
  • 29 Arikan D, Alp H, Gözüm S. et al. Effectiveness of massage, sucrose solution, herbal tea or hydrolysed formula in the treatment of infantile colic. J Clin Nurs 2008; 17 (13) 1754-1761
    CrossrefPubMedGoogle Scholar
  • 30 Savino F, Ceratto S, de Marco A. et al. Looking for new treatments of infantile colic. Ital J Pediatr 2014; 40 (1) 53
    CrossrefPubMedGoogle Scholar
  • 31 Gruber K, Zilkowski I, Turek C. et al. Anthroposophic suppositories for infants and children with abdominal complaints, associated states of restlessness and sleep disorders: Results of a noninterventional study and a retrospective survey. Abstr Merkurstab 2023; 76 (2) 119-123
    PubMedGoogle Scholar
  • 32 Caeser M. Nichtinterventionelle Studien und Gesundheitsökonomie. Pharm Ind 2022; 84 (6) 704-713
    PubMedGoogle Scholar
  • 33 Vogel HH. Wege der Heilmittelfindung. Menschenkunde und Heilmittelerkenntnis. Carum carvi comp., Suppositorien; Carum carvi comp., Suppositorien für Kinder. Bad Boll: Natur-Mensch-Medizin; 1994
    Google Scholar
  • 34 Wolke D, Bilgin A, Samara M. Systematic review and meta-analysis: Fussing and crying durations and prevalence of colic in infants. J Pediatr 2017; 185: 55-61
    CrossrefPubMedGoogle Scholar
  • 35 Soldner G, Stellmann HM. Individuelle Pädiatrie: Leibliche, seelische und geistige Aspekte in Diagnostik und Beratung: anthroposophisch-homöopathische Therapie. 5. Stuttgart: wvg; 2018
    Google Scholar
  • 36 Galland BC, Taylor BJ, Elder DE. et al. Normal sleep patterns in infants and children: A systematic review of observational studies. Sleep Med Rev 2012; 16 (3) 213-222
    CrossrefPubMedGoogle Scholar
  • 37 Theobald K, Capan M, Herbold M. et al. Quality assurance in non-interventional studies. Ger Med Sci 2009 7. Doc29
    PubMedGoogle Scholar
  • 38 Blackburn S, Eheberg D, Plantoer S. et al. Nicht Gegen-, sondern Miteinander: Klinische Studien und Real World Evidence zum Nutzen aller Akteure im Gesundheitswesen kombinieren. Pharm Ind 2018; 80 (6) 808-814
    PubMedGoogle Scholar
  • 39 Goldman M, Beaumont T. A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents. Br J Nurs 2017; 26 (5) 3-10
    CrossrefPubMedGoogle Scholar
  • 40 Steutel NF, Benninga MA, Langendam MW. et al. Reporting outcome measures in trials of infant colic. J Pediatr Gastroenterol Nutr 2014; 59 (3) 341-346
    CrossrefPubMedGoogle Scholar