PDF icon Download PDF
Synfacts 2024; 20(12): 1329
DOI: 10.1055/a-2439-8066
Peptide Chemistry

Peptide Synthesis Using Unprotected Amino Acids

Contributor(s):
Hisashi Yamamoto
,
Kazumasa Kon
Hattori T, * Yamamoto H. * Chubu University, Kasugai, Japan
Peptide Bond Formation Between Unprotected Amino Acids: Convergent Synthesis of Oligopeptides.

J. Am. Chem. Soc 2024;
146: 25738-25744
DOI: 10.1021/jacs.4c08049
CrossrefPubMedSearch in Google Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Keywords

unprotected amino acids - silacyclic dipeptide - convergent synthesis

Significance

Protecting groups for the N-terminal amino and C-terminal carboxyl groups are essential in peptide synthesis. In this work, the authors have developed peptide bond formation between unprotected amino acids using two kinds of appropriate silylating reagents.


 

Comment

Me2Si(Im)2 and TMSIM were used to achieve peptide bond formation chemoselectively between two different unprotected amino acids to give a broad range of silacyclic dipeptides. Also, silacyclic dipeptides were successfully applied to convergent long peptide synthesis.


 

 

Publication History

Article published online:
21 November 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany


  Permissions and Reprints