RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2025; 21(02): 207
DOI: 10.1055/a-2497-0651
DOI: 10.1055/a-2497-0651
Peptide Chemistry
Palladium-Catalyzed Late-Stage Macrocyclization for the Synthesis of Cyclophane-Braced Glycopeptides
Bazzi S,
Mohamed AH,
Ryzhakov D,
Ghouilem J,
Beniddir MA,
Gandon V *,
Messaoudi S *.
Université Paris-Saclay and Institut Polytechnique de Paris, Palaiseau,
France
Diastereoselective Anomeric C(sp3)–H Cyclization Towards the Design of New Cyclophane-Braced Glycopeptides.
Angew. Chem. Int. Ed. 2024;
DOI: 10.1002/anie.202418057
Diastereoselective Anomeric C(sp3)–H Cyclization Towards the Design of New Cyclophane-Braced Glycopeptides.
Angew. Chem. Int. Ed. 2024;
DOI: 10.1002/anie.202418057
Significance
Macrocyclic peptides have gained tremendous attention in peptide drug discovery. In this article, the authors have developed a palladium-catalyzed macrocyclization by selective C(sp3)–H arylation of the anomeric bonds for the synthesis of cyclophane-braced glycopeptides.
#
Comment
A series of macrocyclic cyclophane-braced glycopeptides has been synthesized in good to moderate yields by a palladium-catalyzed site-selective anomeric C(sp3)–H cyclization approach. This protocol showcases the efficiency of a palladium-catalyzed C–H activation strategy for the synthesis of unnatural cyclic peptides.
#
#
Publikationsverlauf
Artikel online veröffentlicht:
28. Januar 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany