Orofacial Cleft and Poor Birth Health Outcomes: A Populational Cross-Sectional Study

Abstract

Objective

This study aimed to examine whether newborns with orofacial clefts are at increased prevalence of poor birth health outcomes.

Study Design

This is a population-based cross-sectional study, conducted with information from 25,879,282 live births registered in the U.S. Vital Statistics Natality Birth Data from 2017 to 2023. The prevalence ratios and logistic regression models between orofacial cleft status (all, isolated, or nonisolated) and each child's birth health variables (delivery method, maternal morbidity, 5-minute Apgar score, gestational age, birth weight, abnormal conditions, infant breastfed at discharge) were calculated, assuming a p ≤ 0.05 as statistically significant.

Results

The prevalence ratios showed that newborns with orofacial clefts were more susceptible to being born by cesarean section (prevalence ratio [PR] = 1.18, p = 0.000, 95% confidence interval [CI] = 1.16–1.21), having lower birth weight (PR = 2.18, p = 0.000, 95% CI = 2.11–2.25), lower Apgar 5 score (PR = 4.08, p = 0.000, 95% CI = 4.08–4.50), prematurity (PR = 1.55, p = 0.000, 95% CI = 1.50–1.60), experiencing more abnormal conditions at birth (PR = 3.72, p = 0.000, 95% CI = 3.64–3.80), and having more difficulty to be breastfed (PR = 2.16, p = 0.000, 95% CI = 2.11–2.22) than newborns without clefts. These ratios were even higher among those with nonisolated orofacial clefts. Associations were statistic significant even after adjustments.

Conclusion

This study provides evidence that newborns with orofacial clefts are at increased prevalence of poor birth health outcomes.

Key Points

• Orofacial clefts are associated to higher prevalence of birth outcomes.

• Newborns with orofacial clefts were more susceptible to have low birth weight.

• Newborns with orofacial clefts were more susceptible to preterm birth.

Keywords

orofacial cleft - population health - cleft lip - cleft palate

Note

Investigators here had no contact with human subjects and the data used are from an open-access information system, available online, in which the data are disbursed without identifying the subjects.

Publikationsverlauf

Eingereicht: 07. Februar 2025

Angenommen: 01. Mai 2025

Artikel online veröffentlicht:
21. Mai 2025

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