Die Körperkomposition vor allogener hämatopoetischer Stammzelltransplantation und ihre Beinflussbarkeit durch Vibrationstraining während der Therapie

Zusammenfassung

Die allogene hämatopoetische Stammzelltransplantation (alloHSZT) ist eine intensive Therapie zur Behandlung hämatologischer (Krebs-)Erkrankungen und ist mit einem erheblichen negativen Einfluss auf die Körperkomposition verbunden. Patienten verlieren stark an Gewicht, v. a. Muskelmasse, wodurch es zu Einschränkungen der körperlichen Leistungsfähigkeit, bis hin zu kritischen Gesundheitszuständen kommt. Demnach haben Patienten, die mit einer größeren Körper- und Muskelmasse und einem höheren Phasenwinkel α (in der Bio-Impedanz-Analyse) in die Therapie starten, ein geringeres Mortalitäts- und Morbiditätsrisiko. Durch ein individuelles, personalisiertes Bewegungsprogramm während der alloHSZT kann zusätzlich ein Erhalt der körperlichen Leistungsfähigkeit erreicht werden. Hierbei stellte sich Vibrationstraining als eine geeignete Trainingsform heraus.

Abstract

The allogeneic hematopoietic stem cell transplantation (alloHSCT) is a very intensive therapy for the treatment of hematological (cancer) diseases and is associated with a significant negative impact on body composition. Patients lose a lot of weight and muscle mass causing limitations in physical performance, up to critical health conditions. Accordingly, patients with higher body and muscle mass and greater phase angle α have a better chance of overall survival. Additionally, an individual exercise program during alloHSCT can also help to maintain physical performance. Vibration training proved to be suitable for patients during alloHSCT.

Schlüsselwörter

Muskelmasse - Risikofaktor - Hämatoonkologie - körperliche Aktivität - Phasenwinkel

Keywords

muscle mass - risk factor - heamato-oncology - physical exercise - phase angle

• Literatur

• 1 Bredella MA. Sex Differences in Body Composition. In: Mauvais-Jarvis F, Hrsg. Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Cham: Springer International Publishing; 2017: 9-27
• 2 Gallagher D, Heymsfield SB, Heo M. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. The American Journal of Clinical Nutrition 2000; 72: 694-701
• 3 Schaap LA, Koster A, Visser M. Adiposity, Muscle Mass, and Muscle Strength in Relation to Functional Decline in Older Persons. Epidemiologic Reviews 2013; 35: 51-65
• 4 Jiang M, Zou Y, Xin Q. et al. Dose–response relationship between body mass index and risks of all-cause mortality and disability among the elderly: A systematic review and meta-analysis. Clinical Nutrition 2019; 38: 1511-1523
• 5 Mitchell WK, Williams J, Atherton P. et al. Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review. Front Physiol 2012; 3: 260
• 6 Fabbri E, Chiles Shaffer N, Gonzalez-Freire M. et al. Early body composition, but not body mass, is associated with future accelerated decline in muscle quality: Body composition predicts future decline in muscle quality. Journal of Cachexia, Sarcopenia and Muscle 2017; 8: 490-499
• 7 Cheung C-L, Lam KSL, Cheung BMY. Evaluation of Cutpoints for Low Lean Mass and Slow Gait Speed in Predicting Death in the National Health and Nutrition Examination Survey 1999–2004. GERONA 2016; 71: 90-95
• 8 Rohm M, Zeigerer A, Machado J. et al. Energy metabolism in cachexia. EMBO Rep 2019; 20
• 9 Barbosa-Silva MCG, Barros AJD, Wang J. et al. Bioelectrical impedance analysis: population reference values for phase angle by age and sex. Am J Clin Nutr 2005; 82: 49-52
• 10 for the Infectious Diseases Working Party EBMT. Styczyński J, Tridello G. et al. Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors. Bone Marrow Transplantation 2020; 55: 126-136
• 11 Michl M. Urban-&-Fischer-Verlag. BASICS Hämatologie. 2019
• 12 Goldberg AL. Protein turnover in skeletal muscle. II. Effects of denervation and cortisone on protein catabolism in skeletal muscle. J Biol Chem 1969; 244: 3223-3229
• 13 Pahl A, Wehrle A, Kneis S. et al. Whole body vibration training during allogeneic hematopoietic cell transplantation—the effects on patients’ physical capacity. Ann Hematol 2020; 99: 635-648
• 14 Hacker ED, Collins E, Park C. et al. Strength Training to Enhance Early Recovery after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 2017; 23: 659-669
• 15 Pahl A, Waibel S, Wehrle A. et al. Cardiopulmonary performance in allogeneic hematopoietic cell transplantation recipients—evaluation of pre-transplant risk assessments. Bone Marrow Transplant 2021;
• 16 Urbain P, Birlinger J, Ihorst G. et al. Body mass index and bioelectrical impedance phase angle as potentially modifiable nutritional markers are independent risk factors for outcome in allogeneic hematopoietic cell transplantation. Ann Hematol 2012;
• 17 Granacher U, Muehlbauer T, Gruber M. A Qualitative Review of Balance and Strength Performance in Healthy Older Adults: Impact for Testing and Training. Journal of Aging Research 2012; 2012: 1-16
• 18 Wiskemann J, Dreger P, Schwerdtfeger R. et al. Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation. Blood 2011; 117: 2604-2613
• 19 Ritzmann R, Kramer A, Gruber M. et al. EMG activity during whole body vibration: motion artifacts or stretch reflexes?. European Journal of Applied Physiology 2010; 110: 143-151
• 20 Rittweger J. Vibration as an exercise modality: how it may work, and what its potential might be. Eur J Appl Physiol 2010; 108: 877-904
• 21 Hazell TJ, Thomas GWR, DeGuire JR. et al. Vertical whole-body vibration does not increase cardiovascular stress to static semi-squat exercise. Eur J Appl Physiol 2008; 104: 903-908
• 22 Belavý DL, Miokovic T, Armbrecht G. et al. Resistive vibration exercise reduces lower limb muscle atrophy during 56-day bed-rest. J Musculoskelet Neuronal Interact 2009; 9: 225-235
• 23 Avelar NC, Simão AP, Tossige-Gomes R. et al. Oxygen consumption and heart rate during repeated squatting exercises with or without whole-body vibration in the elderly. J Strength Cond Res 2011; 25: 3495-3500
• 24 Gojanovic B, Feihl F, Gremion G. et al. Physiological response to whole-body vibration in athletes and sedentary subjects. Physiol Res 2014; 63: 779-792