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DOI: 10.1055/a-2665-0498
Die präoperative Evaluation erwachsener thoraxchirurgischer Patientinnen und Patienten mit onkologisch resektablen Lungentumoren– eine gemeinsame Empfehlung der DGAI, DGT und DGP

Zusammenfassung
Die steigende Inzidenz maligner Lungenerkrankungen sowie neoadjuvanter Therapien und
eine durch das zukünftige Lungenkarzinom-Screening zu erwartende Detektion von operablen
Stadien erfordern vor dem Hintergrund einer Zunahme von Atemwegserkrankungen, speziell
der chronisch obstruktiven Lungenerkrankung (COPD), aber auch interstitieller Lungenerkrankungen,
differenzierte präoperative Entscheidungen über eine funktionelle Operabilität.
Da das postoperative Risiko für kardiovaskuläre und pulmonale Komplikationen nach
einer Lungenresektion mit dem Ausmaß der Lungenparenchymresektion und der vorbestehenden
Einschränkung der Organfunktionen von Herz, Lunge, Niere und Stoffwechsel steigt,
bedürfen auch diese einer besonderen Beachtung. Dies gilt angesichts einer steigenden
Anzahl älterer Patienten über 75 Jahren ebenso für das „Gebrechlichkeitssyndrom“ („Frailty“),
das einen weiteren wesentlichen Parameter bei der strukturierten Evaluation darstellt.
Die aktuelle
Empfehlung soll eine valide und fundierte Entscheidungsgrundlage über die funktionelle
Operabilität eines Patienten mit einem chirurgisch und onkologisch resektablen Lungentumor
aus pneumologischer, thoraxchirurgischer und anästhesiologischer Perspektive schaffen.
Abstract
The increasing incidence of malignant lung diseases, neoadjuvant therapies, and the expected detection of operable stages through future lung cancer screening require differentiated preoperative decisions regarding functional operability against the background of an increase in respiratory diseases, especially COPD, but also interstitial lung diseases. Since the postoperative risk of cardiovascular and pulmonary complications after lung resection increases with the extent of lung parenchymal resection and the pre-existing impairment of organ function of the heart, lungs, kidneys, and metabolism, these also require special attention. Given the increasing number of elderly patients over 75 years of age, this also applies to frailty, which represents another key parameter in structured evaluation.
Publication History
Article published online:
08 August 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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Literatur
- 1 Zöllner C. Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin, Deutsche Gesellschaft für Chirurgie, Deutsche Gesellschaft für Innere Medizin. [Preoperative evaluation of adult patients before elective, non-cardiothoracic surgery: A joint recommendation of the German Society for Anesthesiology and Intensive Care Medicine, the German Society for Surgery and the German Society for Internal Medicine]. Anaesthesiologie 2024; 73: 294-323
- 2 Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin e. V. (DGAI). S3-Leitlinie Perioperative Versorgung von gebrechlichen Patienten. Version 1.0, September 2021. AWMF-Registernummer: 001–048.
- 3 Geraci TC, Ng T. When Is It Safe to Operate for Lung Cancer? Selection of Fiscally Responsible Cardiopulmonary Function Tests for Limited Resection (Wedge Resection and Segmentectomy), Standard Lobectomy, Sleeve Lobectomy, and Pneumonectomy. Thorac Surg Clin 2021; 31: 255-263
- 4 Leitlinienprogramm Onkologie (Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin e. V. [DGP], Deutsche Krebsgesellschaft e. V. [DKG]). S3-Leitlinie Prävention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms. Version 2.0, November 2022: AWMF-Registernummer: 020/007OL.
- 5 Lim E, Baldwin D, Beckles D. et al. Guidelines on the radical management of patients with lung cancer. Thorax 2010; 65 (Suppl. 03) iii1-iii27
- 6 Brunelli A, Charloux A, Bolliger CT. et al. ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). Eur Respir J 2009; 34: 17-41
- 7 Brunelli A, Kim AW, Berger KI. et al. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013; 143 (Suppl. 05) e166S-e190S
- 8 Lee TH, Marcantonio ER, Mangione CM. et al. Derivation and Prospective Validation of a Simple Index for Prediction of Cardiac Risk of Major Noncardiac Surgery. Circulation 1999; 100: 1043-1049
- 9 Kelion AD, Banning AP. Is simple clinical assessment adequate for cardiac risk stratification before elective non-cardiac surgery?. Lancet 1999; 354: 1837-1838
- 10 Postmus PE, Kerr KM, Oudkerk M. et al. Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2017; 28 (Suppl. 04) iv-iv21
- 11 Halvorsen S, Mehilli J, Cassese S. et al. 2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery. Eur Heart J 2022; 43: 3826-3924
- 12 Thompson A, Fleischmann KE, Smilowitz NR. Writing Committee Members. et al. 2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 2024; 84: 1869-1969
- 13 Thomas DC, Blasberg JD, Arnold BN. et al. Validating the thoracic revised cardiac risk index following lung resection. Ann Thorac Surg 2017; 104: 389-394
- 14 Qadri SS, Jarvis M, Ariyaratnam P. et al. Could Thoracoscore predict postoperative mortality in patients undergoing pneumonectomy?. Eur J Cardiothorac Surg 2014; 45: 864-869
- 15 Thangakunam B, Samuel J, Ibrahim B. et al. Lack of Utility of Thoracoscore in Evaluating Fitness for Surgery in Lung Cancer. Indian J Chest Dis Allied Sci 2015; 57: 13-15
- 16 Sharkey A, Ariyaratnam P, Anikin V. et al. Thoracoscore and European Society Objective Score Fail to Predict Mortality in the UK. World J Oncol 2015; 6: 270-275
- 17 Bradley A, Marshall A, Abdelaziz M. et al. Thoracoscore fails to predict complications following elective lung resection. Eur Respir J 2012; 40: 1496-1501
- 18 Alonso M, Popova E, Martin-Grande A. et al. Study protocol for an observational cohort evaluating incidence and clinical relevance of perioperative elevation of high-sensitivity troponin I and N-terminal pro-brain natriuretic peptide in patients undergoing lung resection. BMJ Open 2022; 12: e063778
- 19 Eagle KA, Brundage BH, Chaitman BR. et al. Guidelines for perioperative cardiovascular evaluation for noncardiac surgery. Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Committee on Peroperative Cardiovascular Evaluation for Noncardiac Surgery. Circulation 1996; 93: 1278-1317
- 20 Brunelli A, Varela G, Salati M. et al. Recalibration of the revised cardiac risk index in lung resection candidates. Ann Thorac Surg 2010; 90: 199-203
- 21 Fleisher LA, Fleischmann KE, Auerbach AD. et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 130: 2215-2245
- 22 Kristensen SD, Knuuti J, Saraste A. et al. 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur Heart J 2014; 35: 2383-2431
- 23 Chou J, Ma M, Gylys M. et al. Preexisting Right Ventricular Dysfunction Is Associated With Higher Postoperative Cardiac Complications and Longer Hospital Stay in High-Risk Patients Undergoing Nonemergent Major Vascular Surgery. J Cardiothorac Vasc Anesth 2019; 33: 1279-1286
- 24 Navaratnam M, DiNardo JA. Peri-operative right ventricular dysfunction-the anesthesiologist’s view. Cardiovasc Diagn Ther 2020; 10: 1725-1734
- 25 Leitlinienprogramm Onkologie (Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin e. V. [DGP], Deutsche Krebsgesellschaft e. V. [DKG]). S3-Leitlinie Prävention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms. Version 2.1, Dezember 2022. AWMF-Registernummer: 020/007OL.
- 26 Maconachie R, Mercer T, Navani N. et al. Guideline Committee: Lung cancer: diagnosis and management: summary of updated NICE guidance. BMJ 2019; 364: I1049
- 27 Yu G, Liu X, Li Y. et al. The nomograms for predicting overall and cancer-specific survival in elderly patients with early-stage lung cancer: A population-based study using SEER database. Front Public Health 2022; 10: 946299
- 28 Ma H, Yao D, Cheng J. et al. Older patients more likely to die from cancer-related diseases than younger with stage IA non-small cell lung cancer: a SEER database analysis. J Thorac Dis 2022; 14: 2178-2186
- 29 Srisomboon C, Koizumi K, Haraguchi S. et al. Thoracoscopic surgery for non-small-cell lung cancer: elderly vs. octogenarians. Asian Cardiovasc Thorac Ann 2013; 21: 56-60
- 30 Chan EY, Amirkhosravi F, Nguyen DT. et al. Lobectomy Provides the Best Survival for Stage I Lung Cancer Patients Despite Advanced Age. Ann Thorac Surg 2022; 114: 1824-1832
- 31 Zhang B, Liu R, Ren D. et al. Comparison of Lobectomy and Sublobar Resection for Stage IA Elderly NSCLC Patients (≥ 70 Years): A Population-Based Propensity Score Matching’s Study. Front Oncol 2021; 11: 610638
- 32 de Ruiter JC, Heineman DJ, Danielse JM. et al. The role of surgery for stage I non-small cell lung cancer in octogenarians in the era of stereotactic body radiotherapy in the Netherlands. Lung Cancer 2020; 144: 64-70
- 33 Guo Q, Hu S, Ye J. et al. Surgery offers survival advantage over radiotherapy in patients who are 80 years and older with Stage I and II NSCLC: A retrospective cohort study of 7,045 patients. Front Surg 2022; 9: 1018320
- 34 Bonanno L, Attili I, Pavan A. et al. Treatment strategies for locally advanced non-small cell lung cancer in elderly patients: Translating scientific evidence into clinical practice. Crit Rev Oncol Hematol 2021; 163: 103378
- 35 Shaw JF, Budiansky D, Sharif F. et al. The Association of Frailty with Outcomes after Cancer Surgery: A Systematic Review and Metaanalysis. Ann Surg Oncol 2022; 29: 4690-4704
- 36 Rockwood K, Song X, MacKnight C. et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489-495
- 37 Cappe M, Laterre PF, Dechamps M. Preoperative frailty screening, assessment and management. Curr Opin Anaesthesiol 2023; 36: 83-88
- 38 Hino H, Karasaki T, Yoshida Y. et al. Risk factors for postoperative complications and long-term survival in lung cancer patients older than 80 years. Eur J Cardiothorac Surg 2018; 53: 980-986
- 39 Dunne MJ, Abah U, Scarci M. Frailty assessment in thoracic surgery. Interactive CardioVascular and Thoracic Surgery 2014; 18: 667-670
- 40 Subramaniam S, Aalberg JJ, Soriano RP. et al. New 5-Factor Modified Frailty Index Using American College of Surgeons NSQIP Data. J Am Coll Surg 2018; 226: 173-181
- 41 Cooper L, Gong Y, Dezube AR. et al. Thoracic surgery with geriatric assessment and collaboration can prepare frail older adults for lung cancer surgery. J Surg Oncol 2022; 126: 372-382
- 42 Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004; 240: 205-213
- 43 Endo S, Ikeda N, Kondo T. et al. Model of lung cancer surgery risk derived from a Japanese nationwide web-based database of 78 594 patients during 2014–2015. Eur J Cardiothorac Surg 2017; 52: 1182-1189
- 44 Brunelli A, Chaudhuri N, Kefaloyannis M. et al. Eurolung risk score is associated with long-term survival after curative resection for lung cancer. J Thorac Cardiovasc Surg 2021; 161: 776-786
- 45 Haines K, Agarwal S. Postoperative Pulmonary Complications – A Multifactorial Outcome. JAMA Surg 2017; 152: 166-167
- 46 Jammer I, Wickboldt N, Sander M. et al. Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: a statement from the ESA-ESICM joint taskforce on perioperative outcome measures. Eur J Anaesthesiol 2015; 32: 88-105
- 47 Abbott TEF, Fowler AJ, Pelosi P. et al. A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications. Br J Anaesth 2018; 120: 106-1079
- 48 Dankert A, Dohrmann T, Löser B. et al. Pulmonary Function Tests for the Prediction of Postoperative Pulmonary Complications. Dtsch Arztebl Int 2022; 119: 99-106
- 49 Canet J, Gallart L, Gomar C. et al. Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology 2010; 113: 1338-1350
- 50 Fernandez FG, Kosinski AS, Burfeind W. et al. The Society of Thoracic Surgeons Lung Cancer Resection Risk Model: Higher Quality Data and Superior Outcomes. Ann Thorac Surg 2016; 102: 370-377
- 51 Pezzi CM, Mallin K, Mendez AS. et al. Ninety-day mortality after resection for lung cancer is nearly double 30-day mortality. J Thorac Cardiovasc Surg 2014; 148: 2269-2277
- 52 Hu Y, McMurry TL, Wells KM. et al. Postoperative mortality is an inadequate quality indicator for lung cancer resection. Ann Thorac Surg 2014; 97: 973-979
- 53 Arozullah AM, Daley J, Henderson WG. et al. Multifactorial risk index for predicting postoperative respiratory failure in men after major noncardiac surgery. The National Veterans Administration Surgical Quality Improvement Program. Ann Surg 2000; 232: 242-253
- 54 Im Y, Chung MP, Lee KS. et al. Impact of interstitial lung abnormalities on postoperative pulmonary complications and survival of lung cancer. Thorax 2023; 78: 183-190
- 55 Miller JI, Hatcher CRJr. Limited resection of bronchogenic carcinoma in the patient with marked impairment of pulmonary function. Ann Thorac Surg 1987; 44: 340-343
- 56 Baldi S, Ruffini E, Harari S. et al. Does lobectomy for lung cancer in patients with chronic obstructive pulmonary disease affect lung function?. A multicenter national study J Thorac Cardiovasc Surg 2005; 130: 1616-1622
- 57 Bolliger CT, Perruchoud AP. Functional evaluation of the lung resection candidate. Eur Respir J 1998; 11: 198-212
- 58 Brunelli A, Belardinelli R, Refai M. et al. Peak oxygen consumption during cardiopulmonary exercise test improves risk stratification in candidates to major lung resection. Chest 2009; 135: 1260-1267
- 59 Brunelli A, Refai MA, Salati M. et al. Carbon monoxide lung diffusion capacity improves risk stratification in patients without airflow limitation: evidence for systematic measurement before lung resection. Eur J Cardiothorac Surg 2006; 29: 567-570
- 60 Brunelli A, Refai M, Salati M. et al. Predicted versus observed FEV1 and DLCO after major lung resection: a prospective evaluation at different postoperative periods. Ann Thorac Surg 2007; 83: 1134-1139
- 61 Brunelli A, Sabbatini A, Xiumé F. et al. A model to predict the decline of the forced expiratory volume in one second And the carbon monoxide lung diffusion capacity early after major lung resection. Interact Cardiovasc Thorac Surg 2005; 4: 61-65
- 62 Ferguson MK, Little L, Rizzo L. et al. Diffusing capacity predicts morbidity and mortality after pulmonary resection. J Thorac Cardiovasc Surg 1988; 96: 894-900
- 63 Ferguson MK, Vigneswaran WT. Diffusing capacity predicts morbidity after lung resection in patients without obstructive lung disease. Ann Thorac Surg 2008; 85: 1158-1164
- 64 Wang JS, Abboud RT, Wang LM. Effect of lung resection on exercise capacity and on carbon monoxide diffusing capacity during exercise. Chest 2006; 129: 863-872
- 65 Criee CP, Smith HJ, Preisser AM. et al. [Recommendations on interpretive strategies for routine lung function tests]. Pneumologie 2024; 78: 1003-1013
- 66 Ersoy MY, Keus L, Başer S. et al. Comparing algorithms for the preoperative functional assessment of patients with lung cancer. Chest 2005; 128: 170S
- 67 Ribas J, Díaz O, Barberà JA. et al. Invasive exercise testing in the evaluation of patients at high-risk for lung resection. Eur Respir J 1998; 12: 1429-1435
- 68 Bolliger CT, Jordan P, Solèr M. et al. Exercise capacity as a predictor of postoperative complications in lung resection candidates. Am J Respir Crit Care Med 1995; 151: 1472-1480
- 69 Markos J, Mullan BP, Hillman DR. et al. Preoperative assessment as a predictor of mortality and morbidity after lung resection. Am Rev Respir Dis 1989; 139: 902-910
- 70 Zeiher BG, Gross TJ, Kern JA. et al. Predicting postoperative pulmonary function in patients undergoing lung resection. Chest 1995; 108: 68-72
- 71 Alifano M, Boudaya MS, Salvi M. et al. Pneumonectomy after chemotherapy: morbidity, mortality, and long-term outcome. Ann Thorac Surg 2008; 85: 1866-1872
- 72 Santini M, Fiorello A, Vicidomini G. et al. Role of diffusing capacity in predicting complications after lung resection for cancer. Thorac Cardiovasc Surg 2007; 55: 391-394
- 73 Ferguson MK, Reeder LB, Mick R. Optimizing selection of patients for major lung resection. J Thorac Cardiovasc Surg 1995; 109: 275-281
- 74 Burt BM, Kosinski AS, Shrager JB. et al. Thoracoscopic lobectomy is associated with acceptable morbidity and mortality in patients with predicted postoperative forced expiratory volume in 1 second or diffusing capacity for carbon monoxide less than 40% of normal. J Thorac Cardiovasc Surg 2014; 148: 19-28
- 75 Gooseman MR, Falcoz PE, Decaluwe H. et al. Morbidity and mortality of lung resection candidates defined by the American College of Chest Physicians as ‘moderate risk’: an analysis from the European Society of Thoracic Surgeons database. Eur J Cardiothorac Surg 2021; 60: 91-97
- 76 Guazzi M, Arena R, Halle H. et al. 2016 Focused Update: Clinical recommendations for cardiopulmonary exercise testing date. Assessment in specific patient populations. Circulation 2016; 133: e694-e711
- 77 Older P, Smith R, Courtney P. et al. Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise testing. Chest 1993; 104: 701-704
- 78 Salati M, Brunelli A. Risk Stratification in Lung Resection. Curr Surg Rep 2016; 4: 37
- 79 Older P, Hall A. Clinical review: how to identify high-risk surgical patients. Crit Care 2004; 8: 369-372
- 80 Choi JW, Jeong H, Ahn HJ. et al. The impact of pulmonary function tests on early postoperative complications in open lung resection surgery: an observational cohort study. Sci Rep 2022; 12: 1277
- 81 Guazzi M, Adams V, Conraads V. et al. EACPR/AHA Joint Scientific Statement. Clinical recommendations for cardiopulmonary exercise testing. Data assessment in specific patient populations. Eur Heart J 2012; 33: 2917-2927
- 82 Fletcher GF, Ades PA, Kligfield P. et al. Exercise standards for testing and training. Circulation 2013; 128: 873-934
- 83 Meyer FJ, Borst MM, Buschmann HC. et al. Belastungsuntersuchungen in der Pneumologie – Empfehlungen der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. Pneumologie 2018; 72: 687-731
- 84 Torchio R, Guglielmo M, Giardino R. et al. Exercise ventilatory inefficiency and mortality in patients with chronic obstructive pulmonary disease undergoing surgery for non-small-cell lung cancer. Eur J Cardiothorac Surg 2010; 38: 14-19
- 85 Torchio R, Mazzucco A, Guglielmo M. et al. Minute ventilation to carbon dioxide output (V’E/V'CO2 slope) is the strongest death predictor before larger lung resections. Monaldi Arch Chest Dis 2017; 87: 817
- 86 Gravier FE, Bonnevie T, Boujibar F. et al. Cardiopulmonary exercise testing in patients with non-small cell lung cancer: trust the V˙ O2peak?. J Thorac Dis 2020; 12: 5313-5323
- 87 Smith TP, Kinasewitz GT, Tucker WY. et al. Exercise capacity as a predictor of post-thoracotomy morbidity. Am Rev Respir Dis 1984; 129: 730-734
- 88 Walsh GL, Morice RC, Putnam JBJr. et al. Resection of lung cancer is justified in high-risk patients selected by exercise oxygen consumption. Ann Thorac Surg 1994; 58: 704-710
- 89 Win T, Jackson A, Sharples L. et al. Cardiopulmonary exercise tests and lung cancer surgical outcome. Chest 2005; 127: 1159-1165
- 90 Kristenson K, Hedman K. Percent predicted peak oxygen uptake is superior to weight-indexed peak oxygen uptake in risk stratification before lung cancer lobectomy. J Thorac Cardiovasc Surg 2024; 168: 1375-1384
- 91 Brunelli A, Pompili C, Berardi R. et al. Performance at preoperative stair-climbing test is associated with prognosis after pulmonary resection in stage I non-small cell lung cancer. Ann Thorac Surg 2012; 93: 1796-1800
- 92 Kristenson K, Hylander J, Boros M. et al. Ventilatory efficiency in combination with peak oxygen uptake improves risk stratification in patients undergoing lobectomy. JTCVS Open 2022; 11: 317-326
- 93 Kristenson K, Hylander J, Boros M. et al. VE/VCO(2) slope threshold optimization for preoperative evaluation in lung cancer surgery: identifying true high- and low-risk groups. J Thorac Dis 2024; 16: 123-132
- 94 Vetsch T, Eggmann S, Jardot F. et al. Ventilatory efficiency as a prognostic factor for postoperative complications in patients undergoing elective major surgery: a systematic review. Br J Anaesth 2024; 133: 178-189
- 95 Matsuoka H, Nishio W, Sakamoto T. et al. Prediction of morbidity after lung resection with risk factors using treadmill exercise test. Eur J Cardiothorac Surg 2004; 26: 480-482
- 96 Brunelli A, Salati M. Preoperative evaluation of lung cancer: predicting the impact of surgery on physiology and quality of life. Curr Opin Pulm Med 2008; 14: 275-281
- 97 Choong CK, Meyers BF, Battafarano RJ. et al. Lung cancer resection combined with lung volume reduction in patients with severe emphysema. J Thorac Cardiovasc Surg 2004; 127: 1323-1331
- 98 Matsuoka H, Nishio W, Sakamoto T. et al. Prediction of morbidity after lung resection with risk factors using treadmill exercise test. Eur J Cardiothorac Surg 2004; 26: 480-482
- 99 Wang JS, Abboud RT, Graham BL. Predicted postoperative product and diffusion heterogeneity index in the evaluation of candidates for lung resection. Respir Care 2011; 56: 449-455
- 100 Bernasconi M, Koegelenberg CF, von Groote-Bidlingmaier F. et al. Speed of Ascent During Stair Climbing Identifies Operable Lung Resection Candidates. Respiration 2012; 84: 117-122
- 101 Boujibar F, Gillibert A, Gravier FE. et al. Performance at stair-climbing test is associated with postoperative complications after lung resection: a systematic review and meta-analysis. Thorax 2020; 75: 791-797
- 102 Wesolowski S, Orlowski TM, Kram M. The 6-min walk test in the functional evaluation of patients with lung cancer qualified for lobectomy. Interact Cardiovasc Thorac Surg 2020; 30: 559-564
- 103 Nakagawa T, Tomioka Y, Toyazaki T. et al. Association between values of preoperative 6-min walk test and surgical outcomes in lung cancer patients with decreased predicted postoperative pulmonary function. Gen Thorac Cardiovasc Surg 2018; 66: 220-224
- 104 Boujibar F, Gillibert A, Bonnevie T. et al. The 6-minute stepper test and the sit-to-stand test predict complications after major pulmonary resection via minimally invasive surgery: a prospective inception cohort study. J Physiother 2022; 68: 130-135
- 105 Ofori SN, Marcucci M, Mbuagbaw L. et al. Determinants of tobacco smoking abstinence one year after major noncardiac surgery: a secondary analysis of the VISION study. Br J Anaesth 2022; 129: 497-505
- 106 Balduyck B, Sardari Nia P, Cogen A. et al. The effect of smoking cessation on quality of life after lung cancer surgery. Eur J Cardiothorac Surg 2011; 40: 1432-1437 discussion 1437
- 107 Poghosyan H, Sheldon LK, Leveille SG. et al. Health-related quality of life after surgical treatment in patients with non-small cell lung cancer: a systematic review. Lung Cancer 2013; 81: 11-26
- 108 Heiden BT, Eaton Jr DB, Chang SH. et al. The Impact of Persistent Smoking After Surgery on Long-term Outcomes After Stage I Nonsmall Cell Lung Cancer Resection. Chest 2022; 161: 1687-1696
- 109 Bayley EM, Zhou N, Mitchell KG. et al. Modern Perioperative Practices May Mitigate Effects of Continued Smoking Among Lung Cancer Patients. Ann Thorac Surg 2022; 114: 286-292
- 110 Jeganathan V, Knight S, Bricknell M. et al. Impact of smoking status and chronic obstructive pulmonary disease on pulmonary complications post lung cancer surgery. PLoS One 2022; 17: e0266052
- 111 Yamamichi T, Ichinose J, Iwamoto N. et al. Correlation Between Smoking Status and Short-term Outcome of Thoracoscopic Surgery for Lung Cancer. Ann Thorac Surg 2022; 113: 459-465
- 112 Shima T, Kinoshita T, Uematsu M. et al. How long is cessation of preoperative smoking required to improve postoperative survival of patients with pathological stage I non-small cell lung cancer?. Transl Lung Cancer Res 2020; 9: 1924-1939
- 113 Takenaka T, Shoji F, Tagawa T. et al. Does short-term cessation of smoking before lung resections reduce the risk of complications?. J Thorac Dis 2020; 12: 7127-7134
- 114 Fukui M, Suzuki K, Matsunaga T. et al. Importance of Smoking Cessation on Surgical Outcome in Primary Lung Cancer. Ann Thorac Surg 2019; 107: 1005-1009
- 115 Rodriguez M, Gómez-Hernandez MT, Novoa N. et al. Refraining from smoking shortly before lobectomy has no influence on the risk of pulmonary complications: a case-control study on a matched population. Eur J Cardiothorac Surg 2017; 51: 498-503
- 116 Nakagawa M, Tanaka H, Tsukuma H. et al. Relationship between the duration of the preoperative smoke-free period and the incidence of postoperative pulmonary complications after pulmonary surgery. Chest 2001; 120: 705-710
- 117 Banks KC, Dusendang JR, Schmittdiel JA. et al. Association of Surgical Timing with Outcomes in Early Stage Lung Cancer. World J Surg 2023; 47: 1323-1332
- 118 Hindricks G, Potpara T, Dagres N. et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J 2021; 42: 373-498
- 119 Haverkamp W, Hachenberg T. Post-thoracotomy dysrhythmia. Curr Opin Anaesthesiol 2016; 29: 26-33
- 120 Smith H, Yeung C, Gowing S. et al. A review and analysis of strategies for prediction, prevention and management of post-operative atrial fibrillation after non-cardiac thoracic surgery. J Thorac Dis 2018; 10: S3799-S3808
- 121 Diallo EH, Brouillard P, Raymond JM. et al. Predictors and impact of postoperative atrial fibrillation following thoracic surgery: a state-of-the-art review. Anaesthesia 2023; 78: 491-500
- 122 Frendl G, Sodickson AC, Chung MK. et al. 2014 AATS guidelines for the prevention and management of perioperative atrial fibrillation and flutter for thoracic surgical procedures. J Thorac Cardiovasc Surg 2014; 148: e153-193
- 123 Zhao BC, Huang TY, Deng QW. et al. Prophylaxis Against Atrial Fibrillation After General Thoracic Surgery: Trial Sequential Analysis and Network Meta-Analysis. Chest 2017; 151: 149-159
- 124 Khalil MA, Al-Agaty AE, Ali WG. et al. A comparative study between amiodarone and magnesium sulfate as antiarrhythmic agents for prophylaxis against atrial fibrillation following lobectomy. J Anesth 2013; 27: 56-61
- 125 Smith H, Li H, Brandts-Longtin O. et al. External validity of a model to predict postoperative atrial fibrillation after thoracic surgery. Eur J Cardiothorac Surg 2020; 57: 874-880
- 126 Passman RS, Gingold DS, Amar D. et al. Prediction rule for atrial fibrillation after major noncardiac thoracic surgery. Ann Thorac Surg 2005; 79: 1698-1703
- 127 Arroyo-Hernández M, Maldonado F, Lozano-Ruiz F. et al. Radiationinduced lung injury: current evidence. BMC Pulm Med 2021; 21: 9
- 128 Koryllos A, Lopez-Pastorini A, Zalepugas D. et al. Optimal timing of surgery for bronchial sleeve resection after neoadjuvant chemoradiotherapy. J Surg Oncol 2020; 122: 328-335
- 129 Chriqui LE, Forster C, Lovis A. et al. Is sleeve lobectomy safe after induction therapy? – A systematic review and meta-analysis. J Thorac Dis 2021; 13: 5887-5898
- 130 Tao Y, Zhou Y, Tang L. et al. Toxicity profile of anaplastic lymphoma kinase tyrosine kinase inhibitors for patients with non-small cell lung cancer: A systematic review and meta-analysis. Invest New Drugs 2022; 40: 831-840
- 131 Wang DY, Salem JE, Cohen JV. et al. Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Metaanalysis. JAMA Oncol 2018; 4: 1721-1728
- 132 Ramos-Casals M, Brahmer JR, Callahan MK. et al. Immune-related adverse events of checkpoint inhibitors. Nat Rev Dis Primers 2020; 6: 38
- 133 Fujiu K, Kanno R, Suzuki H. et al. Preoperative pulmonary function as a predictor of respiratory complications and mortality in patiens undergoing lung cancer resection. Fukushima J Med Sci 2003; 49: 117-127
- 134 Leo F, Solli P, Spaggiari L. et al. Respiratory function changes after chemotherapy. Ann Thorac Surg 2004; 77: 260-265
- 135 Matsubara Y, Takeda S, Mashimo T. Risk stratification for lung cancer surgery. Chest 2005; 128: 3519-3525
- 136 Voorn MJJ, Beukers K, Trepels CMM. et al. Associations between pretreatment nutritional assessments and treatment complications in patients with stage I-III non-small cell lung cancer: A systematic review. Clin Nutr ESPEN 2022; 47: 152-162
- 137 Icard P, Schussler O, Loi M. et al. Pre-Disease and Pre-Surgery BMI, Weight Loss and Sarcopenia Impact Survival of Resected Lung Cancer Independently of Tumor Stage. Cancers (Basel) 2020; 12: 266
- 138 Nakagawa T, Toyazaki T, Chiba N. et al. Prognostic value of body mass index and change in body weight in postoperative outcomes of lung cancer surgery. Interact Cardiovasc Thorac Surg 2016; 23: 560-566
- 139 Weiss AJ, Fingar KR, Barrett ML. et al. Characteristics of Hospital Stays Involving Malnutrition, 2013. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016
- 140 Lobo DN, Gianotti L, Adiamah A. et al. Perioperative nutrition: Recommendations from the ESPEN expert group. Clin Nutr 2020; 39: 3211-3227
- 141 Muscaritoli M, Arends J, Bachmann P. et al. ESPEN practical guideline: Clinical Nutrition in cancer. Clin Nutr 2021; 40: 2898-2913
- 142 Loganathan RS, Stover DE, Shi W. et al. Prevalence of COPD in women compared to men around the time of diagnosis of primary lung cancer. Chest 2006; 129: 1305-1312
- 143 Ferreira IM, Brooks D, White J. et al. Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012; 12: CD000998
- 144 Batchelor TJP, Rasburn NJ, Abdelnour-Berchtold E. et al. Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg 2019; 55: 91-115
- 145 Baldwin C, Spiro A, Ahern R. et al. Oral nutritional interventions in malnourished patients with cancer: a systematic review and metaanalysis. J Natl Cancer Inst 2012; 104: 371-385
- 146 Hegazi RA, Hustead DS, Evans DC. Preoperative standard oral nutrition supplements vs immunonutrition: results of a systematic review and meta-analysis. J Am Coll Surg 2014; 219: 1078-1087
- 147 Pirlich M, Schütz T, Norman K. et al. The German hospital malnutrition study. Clin Nutr 2006; 25: 563-572
- 148 Weimann A, Braga M, Carli F. et al. ESPEN practical guideline: Clinical nutrition in surgery. Clin Nutr 2021; 40: 4745-4761
- 149 Kondrup J, Rasmussen HH, Hamberg O. et al. Ad Hoc ESPEN Working Group. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr 2003; 22: 321-336
- 150 Detsky AS, McLaughlin JR, Baker JP. et al. What is subjective global assessment of nutritional status?. JPEN J Parenter Enteral Nutr 1987; 11: 8-13
- 151 Stratton RJ, Hackston A, Longmore D. et al. Malnutrition in hospital outpatients and inpatients: prevalence, concurrent validity and ease of use of the ‘malnutrition universal screening tool’ (‘MUST’) for adults. Br J Nutr 2004; 92: 799-808
- 152 Takahashi M, Sowa T, Tokumasu H. et al. Comparison of three nutritional scoring systems for outcomes after complete resection of non-small cell lung cancer. J Thorac Cardiovasc Surg 2021; 162: 1257-1268.e3
- 153 Cohendy R, Rubenstein LZ, Eledjam JJ. The Mini Nutritional Assessment-Short Form for preoperative nutritional evaluation of elderly patients. Aging (Milano) 2001; 13: 293-297
- 154 Hilty M, Burke C, Pedro H. et al. Disordered microbial communities in asthmatic airways. PLoS One 2010; 5: e8578
- 155 Dickson RP, Erb-Downward JR, Martinez FJ. et al. The Microbiome and the Respiratory Tract. Annu Rev Physiol 2016; 78: 481-504
- 156 Goto T. Airway Microbiota as a Modulator of Lung Cancer. Int J Mol Sci 2020; 21: 3044
- 157 Oxman DA, Issa NC, Marty FM. et al. Postoperative antibacterial prophylaxis for the prevention of infectious complications associated with tube thoracostomy in patients undergoing elective general thoracic surgery: a double-blind, placebo-controlled, randomized trial. JAMA Surg 2013; 148: 440-446
- 158 Licker MJ, Widikker I, Robert J. et al. Operative mortality and respiratory complications after lung resection for cancer: impact of chronic obstructive pulmonary disease and time trends. Ann Thorac Surg 2006; 81: 1830-1837
- 159 Oor JE, Daniels JM, Debets-Ossenkopp YJ. et al. Bronchial colonization and complications after lung cancer surgery. Langenbecks Arch Surg 2016; 401: 885-892
- 160 Jamali S, Dagher M, Bilani N. et al. The Effect of Preoperative Pneumonia on Postsurgical Mortality and Morbidity: A NSQIP Analysis. World J Surg 2018; 42: 2763-2772
- 161 Oparka J, Yan TD, Ryan E. et al. Does video-assisted thoracic surgery provide a safe alternative to conventional techniques in patients with limited pulmonary function who are otherwise suitable for lung resection?. Interact Cardiovasc Thorac Surg 2013; 17: 159-162
- 162 Ceppa DP, Kosinski AS, Berry MF. et al. Thoracoscopic lobectomy has increasing benefit in patients with poorpulmonary function: a society of thoracic surgeons database analysis. Ann Surg 2012; 256: 487-493
- 163 Kachare S, Dexter EU, Nwogu C. et al. Perioperativeoutcomes of thoracoscopic anatomical resections in patients with limited pulmonary reserve. J Thorac Cardiovasc Surg 2011; 141: 459-462
- 164 Lau KK, Martin-Ucar AE, Nakas A. et al. Lung cancer surgery in the Breath-less patient – the benefits of avoiding the gold standard. Eur J Cardiothorac Surg 2010; 38: 6-13
- 165 Kaseda S, Aoki T, Hangai N. et al. Better pulmonary function and prognosis with video-assisted thoracic surgery than with thoracotomy. Ann Thorac Surg 2000; 70: 1644-1646
- 166 Galata C, Karampinis I, Roessner ED. et al. Risk factors for surgical complications after anatomic lung resections in the era of VATS and ERAS. Thorac Cancer 2021; 12: 3255-3262
- 167 Aguinagalde B, Insausti A, Lopez I. et al. VATS lobectomy morbidity and mortality is lower in patients with the same ppoDLCO: Analysis of the database of the Spanish Video-Assisted ThoracicSurgery Group. Arch Bronconeumol 2021; 57: 750-756
- 168 Su H, Yan G, Li Z. et al. Analysis of perioperative complications and related risk factors of thoracotomy and complete video-assisted thoracoscopic surgery lobectomy. Am J Transl Res 2022; 14: 2393-2401
- 169 Detterbeck F, Antonicelli A, Okada M. Results of Video-Assisted Techniques for Resection of Lung Cancer. In: Pass H, Ball D, Scagliotti G. , Hrsg. Thoracic Oncology: The IASLC Multidisciplinary Approach (2nd Edition). IASLC; 2018: 274-282.e2
- 170 Bendixen M, Jørgensen OD, Kronborg C. et al. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol 2016; 17: 836-844
- 171 Detterbeck FC, Mase VJJr, Li AX. et al. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation-part 2: systematic review of evidence regarding resection extent in generally healthy patients. J Thorac Dis 2022; 14: 2357-2386
- 172 Caviezel C, von Rotz J, Schneiter D. et al. Improved postoperative lung function after sublobar resection of non-small-cell lung cancer combined with lung volume reduction surgery in patients with advanced emphysema. J Thor Dis 2018; 10 (Suppl. 23) S2704-S2710
- 173 Yacoub WN, Meyers BF. Surgical resection in combination with lung volume reduction surgery for stage I non-small cell lung cancer. Semin Thorac Cardiovasc Surg 2010; 22: 38-43
- 174 Yun JK, Jeong JH, Lee GD. et al. Predicting Postoperative Complications and Long-Term Survival After Lung Cancer Surgery Using Eurolung Risk Score. J Korean Med Sci 2022; 37: e36
- 175 Mizuguchi S, Iwata T, Izumi N. et al. Arterial blood gases predict longterm prognosis in stage I non-small cell lung cancer patients. BMC Surg 2016; 16: 3
- 176 Sandeep B, Huang X, Li Y. et al. A comparison of regional anesthesia techniques in patients undergoing video-assisted thoracic surgery: A network meta-analysis. Int J Surg 2022; 105: 106840