Panigrahi NR,
Khan SM,
Handoko,
Arora PS *.
New York University, USA
Small Molecule Catalyst for Peptide Synthesis.
J. Am. Chem. Soc. 2025;
147: 25682-25691
DOI:
10.1021/jacs.5c07242
Keywords
catalytic peptide synthesis - arylselenide - phosphine oxide - phase independent -
oligopeptide - redox recycling
Significance
Recent advances in peptide synthesis showcase innovative phosphorus- and selenium-based
catalysts that efficiently promote peptide bond formation in both solution and solid-phase
systems. Operating in eco-friendly solvents, these catalysts exhibit excellent substrate
compatibility, positioning them as promising solutions for sustainable and scalable
peptide synthesis.
Comment
This innovative catalyst design leverages the redox recycling of aryldiselenide and
phosphine oxide, with air as a green oxidant and phenylsilane as the reductant. Easily
synthesized from simple starting materials, it delivers high yields for dipeptide
syntheses, particularly in solid-phase oligopeptide synthesis. Operating in air and
compatible with acetonitrile, this catalyst offers a safer, more sustainable alternative
to DMF, reducing both toxicity and environmental impact.
