Phase-Independent Catalytic Peptide Synthesis

Keywords

catalytic peptide synthesis - arylselenide - phosphine oxide - phase independent - oligopeptide - redox recycling

Significance

Recent advances in peptide synthesis showcase innovative phosphorus- and selenium-based catalysts that efficiently promote peptide bond formation in both solution and solid-phase systems. Operating in eco-friendly solvents, these catalysts exhibit excellent substrate compatibility, positioning them as promising solutions for sustainable and scalable peptide synthesis.

 

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Comment

This innovative catalyst design leverages the redox recycling of aryldiselenide and phosphine oxide, with air as a green oxidant and phenylsilane as the reductant. Easily synthesized from simple starting materials, it delivers high yields for dipeptide syntheses, particularly in solid-phase oligopeptide synthesis. Operating in air and compatible with acetonitrile, this catalyst offers a safer, more sustainable alternative to DMF, reducing both toxicity and environmental impact.

 

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Publication History

Article published online:
23 September 2025