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Synfacts 2025; 21(11): 1095
DOI: 10.1055/a-2703-0718
Synthesis of Materials and Unnatural Products

Macrocycles Excised from COFs

Authors

    Contributor(s):

  • Dahui Zhao

  • Haochen Li

Sánchez-Naya R, Cavalieri JP, Albalad J *, Cortés-Martínez A, Wang K, Fuertes-Espinosa C, Parella T, Fiori S, Ribas E, Mugarza A, Ribas X, Faraudo J, Yaghi OM, Imaz I *, Maspoch D *. CSIC, Universitat Autònoma de Barcelona, and The Barcelona Institute of Science and Technology, Spain
Excision of Organic Macrocycles from Covalent Organic Frameworks.

Science 2025;
388: 1318-1323
DOI: 10.1126/science.adw4126
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Keywords

covalent organic frameworks (COFs) - oligo-amide macrocycles - cleavable COF - C–C double bond cleavage

Significance

Controlled fragmentation of covalent-organic-frameworks (COFs) into well-defined macrocyclic molecules is achieved.


Comment

COFs containing C–C double-bond linkages are first constructed via Schiff base ligation. Upon post-oxidation, imine groups are converted into amides, such that orthogonal ozone oxidation cleavage is conducted with the vinylene units, affording the macrocycle products.




Publication History

Article published online:
30 October 2025

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