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Synfacts 2025; 21(11): 1163
DOI: 10.1055/a-2703-2150
DOI: 10.1055/a-2703-2150
Peptide Chemistry
Late-Stage Functionalization of the Serine Residue of a Peptide Chain
Authors
Guo Z,
Diao T *.
New York University, USA
Late-Stage Serine Modification Enables Noncanonical Peptide Synthesis.
J. Am. Chem. Soc. 2025;
147: 33127-33135
DOI: 10.1021/jacs.5c11065
Late-Stage Serine Modification Enables Noncanonical Peptide Synthesis.
J. Am. Chem. Soc. 2025;
147: 33127-33135
DOI: 10.1021/jacs.5c11065
Significance
Site-selective late-stage functionalizations are effective strategies for enhancing the activity of peptides with complex structures. The authors have demonstrated noncanonical peptide preparation by functionalizing the serine unit of a peptide chain.
Comment
Functionalization of the serine unit of a peptide chain was performed with the help of photocatalysis. The reaction could be applied to oligopeptides in good yields.
Publication History
Article published online:
30 October 2025
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