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Synlett
DOI: 10.1055/a-2704-6331
DOI: 10.1055/a-2704-6331
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Alkynes in Organic Synthesis
The Application of Alkynes as 1,2-Dicarbonyl Substitutes in Organic Synthesis Through Iodination and Kornblum Oxidation
Authors
Supported by: OSHEC, Govt. of Odisha 293/249/OSHEC
Abstract
The 1,2-dicarbonyls are excellent moieties in organic synthesis and they offer scopes for the synthesis of numerous interesting heterocycles. Likewise, the alkynes are widespread in nature and drugs. Herein, this article highlights the application of alkynes in organic synthesis as 1,2-dicarbonyl surrogates by I2/DMSO and NIS/DMSO-mediated oxidations through a cascade of iodination and Kornblum oxidation. These approaches are mild, efficient, and tolerate many functional groups. The NIS/DMSO and iodine–DMSO-mediated oxidation of alkynes to 1,2-dicarbonyl compounds and trapping by several nucleophiles to construct important diversely functionalized heterocycles have been discussed in this article. The state of the art, challenges, and future perspective have been highlighted in the present collection.
Publication History
Received: 30 May 2025
Accepted after revision: 17 September 2025
Accepted Manuscript online:
17 September 2025
Article published online:
28 October 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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