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Synfacts 2025; 21(12): 1195
DOI: 10.1055/a-2720-6730
Synthesis of Materials and Unnatural Products

A Catenane-Stabilized Cyclo[48]carbon

Authors

    Contributor(s):

  • Dahui Zhao

  • Beidi Yu

Gao Y *, Gupta P, Rončević I, Mycroft C, Gates PJ, Parker AW, Anderson HL *. University of Oxford, UK
Solution-Phase Stabilization of a Cyclocarbon by Catenane Formation.

Science 2025;
389: 708-710
DOI: 10.1126/science.ady6054
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Keywords

supramolecular stabilizing effect - cyclocarbons - [4]catenanes - cyclopolyalkynes

Significance

The solution-phase synthesis of a cyclo[48]carbon is accomplished for the first time by employing the supramolecular stabilization strategy. Namely, a catenane motif is used to protect a highly reactive, large cyclopolyalkyne.


Comment

In the obtained [4]catenane structure the cyclo[48]carbon ring is threaded through three smaller macrocycles, which offer effective shielding and protection in spite of the dynamic motion and incomplete encapsulation.




Publication History

Article published online:
26 November 2025

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