Ugi Reaction for the Synthesis of Di- and Tripeptides

Keywords

Ugi reaction - dipeptides - tripeptides - unnatural amino acids

Significance

The Ugi reaction is a multicomponent reaction and is used for the synthesis of a reactive building block in synthetic organic chemistry. In this study, the authors developed a step-economic Ugi reaction for the synthesis of di- and tripeptides using unnatural β-hydroxy and β-mercapto α-amino acids.

Comment

The developed Ugi reaction uses the imine component derived from spiro 3-thiazolines or oxazolines, isocyanates, and amino acid carboxylates for the synthesis of oligopeptides in good yields. This method is a simple and single-step reaction for the synthesis of oligopeptides.

Publication History

Article published online:
16 December 2025