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Synfacts 2026; 22(01): 34
DOI: 10.1055/a-2739-0228
DOI: 10.1055/a-2739-0228
Metals in Synthesis
Nickel-Catalyzed Reductive Coupling of Aryl Halides with 10BF3 to Access Isotopically Labelled Boronates
Authors
Meng C-F,
Zhang B-B,
Liu S,
Liu Q,
Wang Z-X *,
Chen X-Y *.
University of the Chinese Academy of Sciences, Beijing and Binzhou Institute of Technology,
P. R. China
Direct Boron-10 Access: Nickel-Catalyzed Reductive C(sp2)–10B Coupling Utilizing 10BF3 .
Angew. Chem. Int. Ed. 2025;
64: e202513304
DOI: 10.1002/anie.202513304
Direct Boron-10 Access: Nickel-Catalyzed Reductive C(sp2)–10B Coupling Utilizing 10BF3 .
Angew. Chem. Int. Ed. 2025;
64: e202513304
DOI: 10.1002/anie.202513304
Keywords
aryl halides - 10BF3 - C(sp2)–10B coupling - isotopic labelling - nickel catalysis - reductive coupling
Significance
A nickel-catalyzed protocol for the direct reductive C(sp2)–10B coupling of aryl halides with commercially available 10BF3 is reported. Key to success is the in situ generation of an electrophilic borenium ion from 10BF3 using AlCl3 and Hünig's base.
Comment
This novel protocol provides direct access to various isotopically enriched 10B organoboron compounds that can be used in boron neutron capture therapy (BNCT) and in neutron shielding materials.
Publication History
Article published online:
16 December 2025
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