Lewis Acid-catalyzed Formal 1,3-Hydroxy Migration of Arylvinyl Carbinols

Abstract

Although the 1,3-hydroxy migration reaction of arylvinyl carbinols is a valuable molecular transformation, examples of Lewis acid-catalyzed reactions remain quite limited. We found that the target Lewis acid-catalyzed reaction proceeded smoothly when acetone was used as the reaction medium. This catalytic system was applicable to arylvinyl carbinols having electron-deficient aromatic rings, a little-studied and challenging topic in 1,3-hydroxy migration chemistry.

Keywords

1,3-Hydroxy migration - Lewis acids - Cinnamyl alcohols - Arylvinyl carbinols - Catalytic reaction

Publication History

Received: 26 August 2025

Accepted after revision: 06 November 2025

Accepted Manuscript online:
06 November 2025

Article published online:
26 November 2025

• References


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