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DOI: 10.1055/a-2744-2024
HFIP-Promoted Intramolecular Oximation of O-Propargyl Hydroxylamines for the Synthesis of 2-Isoxazolines
Authors
We thank ANRF for funding (CRG/2023/001183).
Dedication
Dedicated to Prof. S. Chandrasekaran: New Synthetic Methods and Strategies in Organic Synthesis.
Abstract
A concise and efficient intramolecular oximation enables the rapid and streamlined synthesis of 2-isoxazolines. This metal-free approach offers a broad substrate scope under mild reaction conditions. The successful demonstration of gram-scale and one-pot synthesis highlights both the versatility and scalability of the method. The synthetic utility of this method is further exemplified by converting 2-isoxazolines into β-hydroxy ketones. This method was further used for the synthesis of firefly luciferase inhibitors.
Keywords
Intramolecular oximation - HFIP - O-Propargyl hydroxylamine - Isoxazoline - One-pot synthesis - Luciferase inhibitorsPublication History
Received: 17 September 2025
Accepted after revision: 11 November 2025
Accepted Manuscript online:
11 November 2025
Article published online:
05 December 2025
© 2025. Thieme. All rights reserved.
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