Subscribe to RSS
DOI: 10.1055/a-2761-1601
Cannabis Use and Intimate Partner Violence During Pregnancy Are Associated with Poorer Postpartum Mental Health
Authors
Funding Information This work was supported by the National Institute of Child Health and Human Development (grant number: R01HD085990) to A.A.L., G.A.B., and J.S.L. (with M.M. as site PI and A.K.N. as Co-I).
Abstract
Objective
Intimate partner violence (IPV) victimization during pregnancy is a pervasive public health problem that is associated with mental health difficulties and increased rates of substance use, including cannabis. Despite being contraindicated by medical professionals, cannabis use during pregnancy is on the rise. Preliminary research among the general population suggests that cannabis use is associated with later mental health difficulties. While pregnancy IPV is associated with poorer postpartum mental health, less is known about the effects of pregnancy cannabis use on postpartum mental health. This study aims to investigate the combined effects of IPV victimization and cannabis use during pregnancy on postpartum mental health.
Study Design
In this study, 257 women were assessed at three points during pregnancy to measure IPV victimization and cannabis use. Then, at 6 months postpartum, women's posttraumatic stress disorder (PTSD), depression, and anxiety symptoms were assessed.
Results
Linear regression analyses revealed that pregnancy IPV victimization was significantly associated with elevated postpartum PTSD (β = 0.21, p = 0.005), depression (β = 0.17, p = 0.022), and anxiety symptoms (β = 0.21, p = 0.008). Pregnancy cannabis use was associated with elevated postpartum PTSD (β = 0.25, p < 0.001) and depression (β = 0.25, p < 0.001) symptoms. The interaction between pregnancy IPV and cannabis use was not significantly associated with postpartum mental health symptoms.
Conclusion
Results suggest that cannabis use during pregnancy, as well as IPV victimization, are independent risk factors for specific postpartum mental health problems. Suggestions for nurses and other medical providers on how to best screen for and counsel pregnant women on cannabis use are discussed.
Key Points
-
IPV during pregnancy is associated with elevated postpartum PTSD, depression, and anxiety symptoms.
-
Cannabis use during pregnancy is associated with elevated postpartum PTSD and depression symptoms.
-
IPV and cannabis use during pregnancy are independent risk factors for postpartum mental health difficulties.
-
Medical professionals should screen for and discuss IPV and cannabis use with pregnant women.
Publication History
Received: 22 November 2024
Accepted: 02 December 2025
Article published online:
18 December 2025
© 2025. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Hien D, Ruglass L. Interpersonal partner violence and women in the United States: an overview of prevalence rates, psychiatric correlates and consequences and barriers to help seeking. Int J Law Psychiatry 2009; 32 (01) 48-55
- 2 Román-Gálvez RM, Martín-Peláez S, Fernández-Félix BM, Zamora J, Khan KS, Bueno-Cavanillas A. Worldwide prevalence of intimate partner violence in pregnancy. A systematic review and meta-analysis. Front Public Health 2021; 9: 738459
- 3 Paulson JL. Intimate partner violence and perinatal post-traumatic stress and depression symptoms: a systematic review of findings in longitudinal studies. Trauma Violence Abuse 2022; 23 (03) 733-747
- 4 Cafferky BM, Mendez M, Anderson JR, Stith SM. Substance use and intimate partner violence: A meta-analytic review. Psychol Violence 2018; 8 (01) 110-131
- 5 Chisholm CA, Bullock L, Ferguson II JEJ. Intimate partner violence and pregnancy: epidemiology and impact. Am J Obstet Gynecol 2017; 217 (02) 141-144
- 6 Bailey BA, Daugherty RA. Intimate partner violence during pregnancy: incidence and associated health behaviors in a rural population. Matern Child Health J 2007; 11 (05) 495-503
- 7 Flanagan JC, Leone RM, Gilmore AK, McClure EA, Gray KM. Association of cannabis use with intimate partner violence among couples with substance misuse. Am J Addict 2020; 29 (04) 323-330
- 8 Miller-Graff LE, Howell KH, Grein K, Keough K. Women's cigarette and marijuana use in pregnancy: identifying the role of past versus recent violence exposure. J Interpers Violence 2021; 36 (7-8): NP3982-NP3998
- 9 American College of Obstetricians and Gynecologists. Marijuana Use During Pregnancy and Lactation. Accessed November 6, 2024 at: https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2017/10/marijuana-use-during-pregnancy-and-lactation
- 10 Nguyen VH, Harley KG. Prenatal cannabis use and infant birth outcomes in the pregnancy risk assessment monitoring system. J Pediatr 2022; 240: 87-93
- 11 Crane NA, Schuster RM, Fusar-Poli P, Gonzalez R. Effects of cannabis on neurocognitive functioning: recent advances, neurodevelopmental influences, and sex differences. Neuropsychol Rev 2013; 23 (02) 117-137
- 12 Davis JP, Pedersen ER, Tucker JS. et al. Directional associations between cannabis use and anxiety symptoms from late adolescence through young adulthood. Drug Alcohol Depend 2022; 241: 109704
- 13 Feingold D, Weiser M, Rehm J, Lev-Ran S. The association between cannabis use and anxiety disorders: Results from a population-based representative sample. Eur Neuropsychopharmacol 2016; 26 (03) 493-505
- 14 Agrawal A, Rogers CE, Lessov-Schlaggar CN, Carter EB, Lenze SN, Grucza RA. Alcohol, cigarette, and cannabis use between 2002 and 2016 in pregnant women from a nationally representative sample. JAMA Pediatr 2019; 173 (01) 95-96
- 15 Young-Wolff KC, Sarovar V, Tucker LY. et al. Self-reported daily, weekly, and monthly cannabis use among women before and during pregnancy. JAMA Netw Open 2019; 2 (07) e196471
- 16 Chiu V, Leung J, Hall W, Stjepanović D, Degenhardt L. Public health impacts to date of the legalisation of medical and recreational cannabis use in the USA. Neuropharmacology 2021; 193: 108610
- 17 Young-Wolff KC, Tucker LY, Alexeeff S. et al. Trends in self-reported and biochemically tested marijuana use among pregnant females in California from 2009-2016. JAMA 2017; 318 (24) 2490-2491
- 18 Volkow ND, Han B, Compton WM, McCance-Katz EF. Self-reported medical and nonmedical cannabis use among pregnant women in the United States. JAMA 2019; 322 (02) 167-169
- 19 Carlini BH, Schauer GL. Cannabis-only use in the USA: prevalence, demographics, use patterns, and health indicators. J Cannabis Res 2022; 4 (01) 39
- 20 Young-Wolff KC, Sarovar V, Tucker LY. et al. Trends in cannabis polysubstance use during early pregnancy among patients in a large health care system in Northern California. JAMA Netw Open 2022; 5 (06) e2215418
- 21 Brown QL, Shmulewitz D, Sarvet AL, Young-Wolff KC, Howard T, Hasin DS. Cannabis use, cannabis use disorder and mental health disorders among pregnant and postpartum women in the US: A nationally representative study. Drug Alcohol Depend 2023; 248: 109940
- 22 Young-Wolff KC, Sarovar V, Tucker LY. et al. Association of depression, anxiety, and trauma with cannabis use during pregnancy. JAMA Netw Open 2020; 3 (02) e1921333
- 23 Vanstone M, Panday J, Popoola A. et al. Pregnant people's perspectives on cannabis use during pregnancy: a systematic review and integrative mixed-methods research synthesis. J Midwifery Womens Health 2022; 67 (03) 354-372
- 24 Davis JP, Pedersen ER, Tucker JS. et al. Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences. Addiction 2023; 118 (06) 1083-1092
- 25 Metrik J, Stevens AK, Gunn RL, Borsari B, Jackson KM. Cannabis use and posttraumatic stress disorder: prospective evidence from a longitudinal study of veterans. Psychol Med 2022; 52 (03) 446-456
- 26 Feingold D, Weiser M, Rehm J, Lev-Ran S. The association between cannabis use and mood disorders: a longitudinal study. J Affect Disord 2015; 172: 211-218
- 27 Degenhardt L, Coffey C, Romaniuk H. et al. The persistence of the association between adolescent cannabis use and common mental disorders into young adulthood. Addiction 2013; 108 (01) 124-133
- 28 Alhusen JL, Ray E, Sharps P, Bullock L. Intimate partner violence during pregnancy: maternal and neonatal outcomes. J Womens Health (Larchmt) 2015; 24 (01) 100-106
- 29 DeJonghe ES, Bogat GA, Levendosky AA, von Eye A. Women survivors of intimate partner violence and post-traumatic stress disorder: prediction and prevention. J Postgrad Med 2008; 54 (04) 294-300
- 30 Huth-Bocks AC, Krause K, Ahlfs-Dunn S, Gallagher E, Scott S. Relational trauma and posttraumatic stress symptoms among pregnant women. Psychodyn Psychiatry 2013; 41 (02) 277-301
- 31 Levendosky AA, Bogat GA, Lonstein J, Muzik M, Nuttall AK. Longitudinal prospective study examining the effects of the timing of prenatal stress on infant and child regulatory functioning: the Michigan prenatal stress study protocol. BMJ Open 2021; 11 (09) e054964
- 32 Marshall LL. Development of the severity of violence against women scales. J Fam Viol 1992; 7 (02) 103-121
- 33 Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL. The posttraumatic stress disorder checklist for DSM-5 (PCL-5): development and initial psychometric evaluation. J Trauma Stress 2015; 28 (06) 489-498
- 34 Forkus SR, Raudales AM, Rafiuddin HS, Weiss NH, Messman BA, Contractor AA. The posttraumatic stress disorder (PTSD) Checklist for DSM–5: A systematic review of existing psychometric evidence. Clin Psychol (New York) 2023; 30 (01) 110-121
- 35 Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 1987; 150 (06) 782-786
- 36 Levis B, Negeri Z, Sun Y, Benedetti A, Thombs BD. DEPRESsion Screening Data (DEPRESSD) EPDS Group. Accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for screening to detect major depression among pregnant and postpartum women: systematic review and meta-analysis of individual participant data. BMJ 2020; 371: m4022
- 37 Spielberger CD, Gonzalez-Reigosa F, Martinez-Urrutia A, Natalicio LFS, Natalicio DS. The state-trait anxiety inventory. Interam J Psychol 2017; 5 (3–4):
- 38 Skapinakis P. Spielberger State-Trait Anxiety Inventory. In: Michalos AC. ed. Encyclopedia of Quality of Life and Well-Being Research. Springer Netherlands; 2014: 6261-6264
- 39 Jaccard J, Wan CK, Turrisi R. The detection and interpretation of interaction effects between continuous variables in multiple regression. Multivariate Behav Res 1990; 25 (04) 467-478
- 40 Dolbier CL, Rush TE, Sahadeo LS, Shaffer ML, Thorp J. Community Child Health Network Investigators. Relationships of race and socioeconomic status to postpartum depressive symptoms in rural African American and non-Hispanic White women. Matern Child Health J 2013; 17 (07) 1277-1287
- 41 Pooler J, Perry DF, Ghandour RM. Prevalence and risk factors for postpartum depressive symptoms among women enrolled in WIC. Matern Child Health J 2013; 17 (10) 1969-1980
- 42 Farris SG, Metrik J. Acute effects of cannabis on breath-holding duration. Exp Clin Psychopharmacol 2016; 24 (04) 305-312
- 43 Miller LJ. Psychological, Behavioral, and Cognitive Changes During Pregnancy and the Postpartum Period. In: Wenzel A. ed. The Oxford Handbook of Perinatal Psychology. Oxford University Press; 2016. 0
- 44 Latuskie KA, Andrews NCZ, Motz M. et al. Reasons for substance use continuation and discontinuation during pregnancy: A qualitative study. Women Birth 2019; 32 (01) e57-e64
- 45 Serino Ma D, Peterson Md BS, Rosen Md TS. Psychological functioning of women taking illicit drugs during pregnancy and the growth and development of their offspring in early childhood. J Dual Diagn 2018; 14 (03) 158-170
- 46 Ceasar RC, Gould E, Stal J. et al. Legislation has changed but issues remain: provider perceptions of caring for people who use cannabis during pregnancy in safety net health settings, a qualitative pilot study. Womens Health Rep (New Rochelle) 2023; 4 (01) 400-408
- 47 Panday J, Taneja S, Popoola A. et al. Clinician responses to cannabis use during pregnancy and lactation: a systematic review and integrative mixed-methods research synthesis. Fam Pract 2022; 39 (03) 504-514
- 48 Chang JC, Tarr JA, Holland CL. et al. Beliefs and attitudes regarding prenatal marijuana use: perspectives of pregnant women who report use. Drug Alcohol Depend 2019; 196: 14-20
