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Synlett
DOI: 10.1055/a-2778-8313
DOI: 10.1055/a-2778-8313
Letter
The Synthesis of Amides by Photoexcited o-Nitrophenyl Benzyl Ethers and Evaluation of Biological Activity
Authors
We are grateful for financial support from the National Natural Science Foundation of China (22301261), the Natural Science Foundation of Shandong Province (ZR2023QB012), the Science and Technology Support Program for Youth Innovation in Universities of Shandong Province (2023KJ367) and Scientific Research Foundation for Doctor of Yantai University (YX22B87).
Supported by: Science and Technology Support Program for Youth Innovation in Universities of Shandong Province 2023KJ367 Supported by: Natural Science Foundation of Shandong Province ZR2023QB012 Supported by: National Natural Science Foundation of China 22301261
Abstract
Herein, we have developed a method for the synthesis of amides, novel photoproducts obtained from photoexcited o-nitrophenyl benzyl ethers in metal-free conditions. Furthermore, evaluation of the biological activity revealed that compound 2s exhibits inhibitory effect on LPS-induced NO release in RAW 264.7 cells.
Publication History
Received: 03 December 2025
Accepted after revision: 23 December 2025
Accepted Manuscript online:
24 December 2025
Article published online:
23 January 2026
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References
- 1 Nepali K, LEE H-Y, Liou J-P. J Med Chem 2019; 62: 2851
- 2a Hashimoto S, Sunamoto J, Fujii H, Kano K. Bull Chem Soc Jpn 1968; 41: 1249
- 2b Hurley R, Testa AC. J Am Chem Soc 1966; 88: 4330
- 2c Janzen EG. J Am Chem Soc 1965; 87: 3531
- 2d Mauser H, Heitzer H. Zur Z Naturforsch 1965; 20b: 200
- 2e Ward RL. J Chem Phys 1963; 38: 2588
- 3 Wise DE, Gogarnoiu ES, Duke AD. et al. J Am Chem Soc 2022; 144: 15437
- 4 Ruffoni A, Hampton C, Simonetti M, Leonori D. Nature 2022; 610: 81
- 5a Kammari L, Šolomek T, Ngoy BP, Heger D, Klán P. J Am Chem Soc 2010; 132: 11431
- 5b Polášek M, Tureček F. J Am Chem Soc 2000; 122: 9511
- 5c Negele S, Wieser K, Severin T. J Org Chem 1998; 63: 1138
- 5d Döpp D, Brugger E. Liebigs Ann Chem 1979; 1979: 1965
- 5e Libman J, Berman E. Tetrahedron Lett 1977; 18: 2191
- 5f Weller JW, Hamilton GA. J Chem Soc D: Chem Commun 1970; 1390
- 5g Cuomo VD, Romano C, Procter DJ. Angew Chem Int Ed 2025; 64: e202509244
- 5h Huang H, Jiang Y, Yuan W, Lin Y-M. Angew Chem Int Ed 2024; 63: e202409653
- 5i Mitchell JK, Hussain WA, Bansode AH. et al. Org Lett 2023; 25: 6517
- 5j Paolillo JM, Duke AD, Gogarnoiu ES, Wise DE, Parasram M. J Am Chem Soc 2023; 145: 2794
- 5k Wang B, Ma J, Ren H. et al. Chin Chem Lett 2022; 33: 2420
- 5l Wang B, Ren H, Cao H-J, Lu C, Yan H. Chem Sci 2022; 13: 11074
- 5m Lu C, Su Z, Jing D. et al. Org Lett 2019; 21: 1438
- 6 McMahon RE. Tetrahedron Lett 1966; 7: 2307
- 7 Oguchi S, Torizuka H. Bull Chem Soc Jpn 1980; 53: 2425
- 8 Wang Z, Zhai X, Bai P. et al. Green Chem 2025; 27: 13427
- 9 Meanwell NA. J Med Chem 2018; 61: 5822
- 10 Wang G, Chen X, Zhang Y, Yao W, Ma C. Org Lett 2013; 15: 3066
- 11a Narayanan K, Griffith OW. J Med Chem 1994; 37: 885
- 11b Corbett JA, Sweetland MA, Wang JL, Lancaster JR, McDaniel ML. Proc Natl Acad Sci USA 1993; 90: 1731
- 11c Miller MJS, Sadowska-Krowicka H, Chotinaruemol S, Kakkis JL, Clark DA. J Pharmacol Exp Ther 1993; 264: 11
- 11d Wright CE, Rees DD, Moncada S. Cardiovasc Res 1992; 26: 48
- 11e Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. Proc Natl Acad Sci USA 1991; 88: 6368
- 11f Kilbourn RG, Jubran A, Gross SS. et al. Biochem Biophys Res Commun 1990; 172: 1132
For earlier studies, see:
For studies during this decade, see: