Hydrosilane-Promoted Dehalogenation of Heteroaryl Halides under Air Conditions

Abstract

An efficient dehalogenation reaction of α-substituted halogenated heterocycles catalyzed by Pd/C with triethylsilane (TES) was developed. This study explores the catalytic dehalogenation of N-heteroaryl halides using a Pd/C-K₂CO₃ system, with TES serving as the hydrogen source under air conditions (air and moisture). The reaction conditions are compatible with various functional groups with good to excellent yields.

Keywords

Hydrodehalogenation - N-Heteroaryl halides - Pd/C catalyst - Triethylsilane

Publikationsverlauf

Eingereicht: 02. Dezember 2025

Angenommen nach Revision: 09. Februar 2026

Accepted Manuscript online:
10. Februar 2026

Artikel online veröffentlicht:
19. Februar 2026

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