Sonogashira Couplings of Aryl Bromides at Room Temperature
in Water

doi:10.1055/s-0028-1083586

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Synfacts 2008(12): 1316-1316
DOI: 10.1055/s-0028-1083586

Metal-Mediated Synthesis

Sonogashira Couplings of Aryl Bromides at Room Temperature in Water

Contributor(s): Paul Knochel, Andrei Gavryushin
B. H. Lipshutz*, D. W. Chung, B. Rich
University of California, Santa Barbara, USA

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Publikationsverlauf

Publikationsdatum:
20. November 2008 (online)

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Significance

Terminal alkynes react with aryl bromides in water at ambient temperature in the presence of an amphiphilic nanomicelle-forming reagent PTS. The development of new processes using pure water as a solvent is quite important for the chemical industry, since they allow decreasing the amount of the produced wastes as well as the manufacturing costs of products.