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Synfacts 2008(12): 1289-1289  
DOI: 10.1055/s-0028-1087322
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Nickel-Catalyzed Asymmetric Nazarov Cyclization

Contributor(s): Mark Lautens, Jane Panteleev
I. Walz, A. Togni*
Swiss Federal Institute of Technology, ETH Zürich, Switzerland
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

The authors report an extension on the asymmetric Nazarov cyclization. By utilizing a pigiphos ligand complexed to nickel, cyclization of highly substituted divinyl ketones is possible, many of which have not been previously examined under catalytic conditions.