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Synfacts 2009(4): 0436-0436  
DOI: 10.1055/s-0028-1087822
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed C-H Activation/Aryl-Aryl Coupling of Aromatic Acids

Contributor(s): Paul Knochel, Andrei Gavryushin
D.-H. Wang, T.-S. Mei, J.-Q. Yu*
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

A new catalytic system for C-H activation/C-C coupling is disclosed. It offers a greatly broadened scope compared to the previous method by using aryl trifluoroborates as coupling partners and O2 or air as the oxidant. This protocol provides a preparative route for compounds not assessible via ortho-metalation/cross-coupling sequences like, for instance, highly electron-deficient arenes and various substituted phenyl acetic acids.