Synthesis of Callystatin A

H. A. Reichard; J. C. Rieger; G. C. Micalizio

doi:10.1055/s-0028-1088082

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Synfacts 2009(4): 0355-0355
DOI: 10.1055/s-0028-1088082

Synthesis of Natural Products and Potential Drugs

Synthesis of Callystatin A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
H. A. Reichard, J. C. Rieger, G. C. Micalizio*
Yale University, New Haven, USA

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Publication History

Publication Date:
23 March 2009 (online)

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Significance

Callystatin A is a member of the leptomycin family of natural products which show cell-cycle regulating, antifungal and antiviral activities. The key step of this relatively short and convergent synthesis is a titanium alkoxide-mediated reductive alkyne-alkyne cross-coupling.