ABSTRACT
We describe a 10-day-old male presenting with drop foot and immobility in his right
leg; no abnormality in physical examination had been found upon delivery or discharge.
Magnetic resonance imaging showed a pelvic mass with an extension to the great sciatic
foramen. Fine-needle aspiration biopsy revealed congenital infantile fibrosarcoma.
He was started on vincristine, actinomycin-D, cyclophosphamide chemotherapy. However,
he died soon after the second cycle due to veno-occlusive disease of the liver. Differential
diagnosis of drop foot and immobility in lower extremity must include infiltrating
neoplasms in pelvis.
KEYWORDS
Infantile fibrosarcoma - pelvis - drop foot - immobility - leg
REFERENCES
- 1
Soule E H, Pritchard D J.
Fibrosarcoma in infants and children: a review of 110 cases.
Cancer.
1977;
40
1711-1721
- 2
Chung E B, Enzinger F M.
Infantile fibrosarcoma.
Cancer.
1976;
38
729-739
- 3
Lee M J, Cairns R A, Munk P L, Poon P Y.
Congenital-infantile fibrosarcoma: magnetic resonance imaging findings.
Can Assoc Radiol J.
1996;
47
121-125
- 4
Cofer B R, Vescio P J, Wiener E S.
Infantile fibrosarcoma: complete excision is the appropriate treatment.
Ann Surg Oncol.
1996;
3
159-161
- 5
Nonaka D, Sun C C.
Congenital fibrosarcoma with metastasis in a fetus.
Pediatr Dev Pathol.
2004;
7
187-191
- 6
Fisher C.
Myofibroblastic malignancies.
Adv Anat Pathol.
2004;
11
190-201
- 7
Coffin C M, Dehner L P.
Fibroblastic-myofibroblastic tumors in children and adolescents: a clinicopathologic
study of 108 examples in 103 patients.
Pediatr Pathol.
1991;
11
569-588
- 8
Stout A P.
Fibrosarcoma in infants and children.
Cancer.
1962;
15
1028-1040
- 9
Yalcin B, Leblebicioğlu G, Güler E et al..
Congenital infantile fibrosarcoma of the thigh in a newborn.
Tumori.
2001;
87
436-438
- 10
Shetty A K, Yu L C, Gardner R V, Warrier R P.
Role of chemotherapy in the treatment of infantile fibrosarcoma.
Med Pediatr Oncol.
1999;
33
425-427
- 11
Arndt C, Hawkins D, Anderson J R et al..
Age is a risk factor for chemotherapy-induced hepatopathy with vincristine, dactinomycin
and cyclophosphamide.
J Clin Oncol.
2004;
22
1894-1901
Serhan KüpeliM.D.
Institute of Oncology, Department of Pediatric Oncology, Hacettepe University
Ankara, Turkey
Email: serkupeli@yahoo.com