Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(5): 0530-0530
DOI: 10.1055/s-0029-1216587
DOI: 10.1055/s-0029-1216587
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
CoCl2-Catalyzed Reductive Cyclization of Nitro Cyclic Sulfites
A. R. Jagdale, R. S. Reddy, A. Sudalai*
National Chemical Laboratory, Pune, India
Further Information
Publication History
Publication Date:
22 April 2009 (online)
Significance
A new method for the asymmetric synthesis of tetrahydroquinolin-3-ols is described. The procedure involves a cobalt-catalyzed, one-pot reductive cyclization of nitro cyclic sulfites in the presence of sodium borohydride. The resulting 3-substituted tetrahydroquinoline derivatives are obtained in high yield and enantioselectivity.