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Synfacts 2009(6): 0617-0617
DOI: 10.1055/s-0029-1216657
DOI: 10.1055/s-0029-1216657
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New York
Syntheses in a Ball Mill
Contributor(s):Timothy M. Swager, Jeewoo LimB. Içli, N. Christinat, J. Tönnemann, C. Schüttler, R. Scopelliti, K. Severin*
École Polytechnique Fédérale de Lausanne, Switzerland
Synthesis of Molecular Nanostructures by Multicomponent Condensation Reactions in a Ball Mill
J. Am. Chem. Soc. 2009, 131: 3154-3155
École Polytechnique Fédérale de Lausanne, Switzerland
Synthesis of Molecular Nanostructures by Multicomponent Condensation Reactions in a Ball Mill
J. Am. Chem. Soc. 2009, 131: 3154-3155
Further Information
Publication History
Publication Date:
25 May 2009 (online)
Key words
ball mill - multicomponent condensation - cage molecules
Significance
The authors report the syntheses of cage-like molecules represented by 1 in the scheme above to demonstrate the utility of solid-state reactions in a ball mill. The synthesis of 1 involves the formation of 18 new covalent bonds and proceeds very efficiently in a ball mill.
Comment
The authors report that the solvent-free synthesis of 1 proceeds in 94% yield in a ball mill while the same reaction in ethanol and tetrahydrofuran gives only 56% and 24% yield, respectively.