Synthesis of Coralydine

doi:10.1055/s-0029-1217241

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Synfacts 2009(7): 0707-0707
DOI: 10.1055/s-0029-1217241

Synthesis of Natural Products and Potential Drugs

Synthesis of Coralydine

Contributor(s): Philip Kocienski, Indu Dager
M. Chaumontet, R. Piccardi, O. Baudoin*
Université Claude Bernard Lyon 1, Villeurbanne and Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France

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Publication History

Publication Date:
22 June 2009 (online)

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Significance

The synthesis portrayed here utilizes a Pd-catalyzed C(sp^³)-H activation to form benzocyclobutene ester B. Various 3,4-dihydro-isoquinolines are synthesized using C-H activation and a tandem electrocyclic ring opening-6π-electrocyclization of different iminobenzocyclobutenes.