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Synfacts 2009(7): 0760-0760  
DOI: 10.1055/s-0029-1217298
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Carbon Isotope Chirality Initiated Asymmetric Autocatalysis

Contributor(s): Hisashi Yamamoto, Pingfan Li
T. Kawasaki, Y. Matsumura, T. Tsutsumi, K. Suzuki, M. Ito, K. Soai*
Tokyo University of Science, Japan
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Soai’s asymmetric autocatalysis ­reaction is extended to the use of carbon isotope (¹³C/¹²C) chirality for inducing a very small enan­tiomeric excess of zinc alkoxide product, which gets amplified through subsequent enhancement. Such carbon isotopic chirality would be very difficult to be recognizable by any other methods known to date.