Formal Synthesis of ()-Roseophilin

A. Y. Bitar; A. J. Frontier

doi:10.1055/s-0029-1217579

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Synfacts 2009(8): 0824-0824
DOI: 10.1055/s-0029-1217579

Synthesis of Natural Products and Potential Drugs

Formal Synthesis of ()-Roseophilin

Contributor(s): Philip Kocienski, Stewart Eccles
A. Y. Bitar, A. J. Frontier*
University of Rochester, USA

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Publication History

Publication Date:
23 July 2009 (online)

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Significance

Roseophilin was isolated from Streptomyces griseoviridis and showed lower than 1 µM IC₅₀ values against K562 human erythroid leukemia and KB human epidermoid carcinoma cells. Interestingly, the unnatural enantiomer was 2-10 fold more potent.