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Synfacts 2009(10): 1172-1172  
DOI: 10.1055/s-0029-1217878
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Mukaiyama Aldol Reaction with Al-MCM-41

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
S. Ito, H. Yamaguchi, Y. Kubota, M. Asami*
Yokohama National University, Japan
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Aluminum-incorporated MCM-41 (Al-MCM-41) catalyzed the Mukaiyama aldol reaction of aldehydes 1 with silyl enol ethers 2 to give the corresponding aldol adducts 3 in 67-99% yield (17 examples). The catalyst was recovered by filtration and reused three times without significant loss of activity for formation of 3a (1st reuse: 0.25 h, 99%, 2nd reuse: 0.25 h, 86%, 3rd reuse: 1 h, 85%).